IFNA1_CHICK
ID IFNA1_CHICK Reviewed; 193 AA.
AC P42165;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Interferon type A1/A2;
DE Flags: Precursor;
GN Name=IFNA1;
GN and
GN Name=IFNA2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7521382; DOI=10.1089/jir.1994.14.71;
RA Sekellick M.J., Ferrandino A.F., Hopkins D.A., Marcus P.I.;
RT "Chicken interferon gene: cloning, expression, and analysis.";
RL J. Interferon Res. 14:71-79(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=White leghorn; TISSUE=Spleen;
RX PubMed=8631799; DOI=10.1074/jbc.271.13.7635;
RA Sick C., Schultz U., Staeheli P.;
RT "A family of genes coding for two serologically distinct chicken
RT interferons.";
RL J. Biol. Chem. 271:7635-7639(1996).
CC -!- FUNCTION: Has antiviral activities.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Appears first at 3 hours post-infection, increases
CC to give the strongest signal at about 9 hours and gradually wanes to
CC almost nothing at 24 hours.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; U07868; AAA50213.1; -; mRNA.
DR EMBL; X92477; CAA63215.1; -; Genomic_DNA.
DR EMBL; X92476; CAA63214.1; -; Genomic_DNA.
DR PIR; I50693; I50693.
DR RefSeq; NP_990758.1; NM_205427.1.
DR RefSeq; XP_004937152.1; XM_004937095.2.
DR RefSeq; XP_004937153.1; XM_004937096.2.
DR RefSeq; XP_015132923.1; XM_015277437.1.
DR RefSeq; XP_015132925.1; XM_015277439.1.
DR AlphaFoldDB; P42165; -.
DR SMR; P42165; -.
DR STRING; 9031.ENSGALP00000021594; -.
DR PaxDb; P42165; -.
DR Ensembl; ENSGALT00000091729; ENSGALP00000071578; ENSGALG00000053752.
DR Ensembl; ENSGALT00000092218; ENSGALP00000070696; ENSGALG00000047630.
DR Ensembl; ENSGALT00000101642; ENSGALP00000071267; ENSGALG00000046996.
DR Ensembl; ENSGALT00000102661; ENSGALP00000070204; ENSGALG00000048874.
DR Ensembl; ENSGALT00000107243; ENSGALP00000069151; ENSGALG00000050924.
DR GeneID; 100857744; -.
DR GeneID; 100857947; -.
DR GeneID; 100858177; -.
DR GeneID; 396398; -.
DR KEGG; gga:100857744; -.
DR KEGG; gga:100857947; -.
DR KEGG; gga:100858177; -.
DR KEGG; gga:100859032; -.
DR KEGG; gga:396398; -.
DR CTD; 396398; -.
DR VEuPathDB; HostDB:geneid_396398; -.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; P42165; -.
DR OMA; KIPPECW; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; P42165; -.
DR TreeFam; TF336177; -.
DR Reactome; R-GGA-909733; Interferon alpha/beta signaling.
DR Reactome; R-GGA-912694; Regulation of IFNA/IFNB signaling.
DR PRO; PR:P42165; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000046996; Expressed in brain and 3 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR InterPro; IPR015588; Interferon_beta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..193
FT /note="Interferon type A1/A2"
FT /id="PRO_0000016428"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..129
FT /evidence="ECO:0000250"
FT DISULFID 61..155
FT /evidence="ECO:0000255"
FT DISULFID 68..168
FT /evidence="ECO:0000250"
FT VARIANT 65
FT /note="N -> S"
SQ SEQUENCE 193 AA; 22116 MW; 35AF74479C450A15 CRC64;
MAVPASPQHP RGYGILLLTL LLKALATTAS ACNHLRPQDA TFSHDSLQLL RDMAPTLPQL
CPQHNASCSF NDTILDTSNT RQADKTTHDI LQHLFKILSS PSTPAHWNDS QRQSLLNRIH
RYTQHLEQCL DSSDTRSRTR WPRNLHLTIK KHFSCLHTFL QDNDYSACAW EHVRLQARAW
FLHIHNLTGN TRT
