IFNA1_HORSE
ID IFNA1_HORSE Reviewed; 184 AA.
AC P05003;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Interferon alpha-1;
DE Flags: Precursor;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3022999; DOI=10.1089/dna.1986.5.345;
RA Himmler A., Hauptmann R., Adolf G.R., Swetly P.;
RT "Molecular cloning and expression in Escherichia coli of equine type I
RT interferons.";
RL DNA 5:345-356(1986).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M14540; AAA30953.1; -; Genomic_DNA.
DR PIR; A24912; IVHOA1.
DR RefSeq; XP_003364009.1; XM_003363961.2.
DR AlphaFoldDB; P05003; -.
DR SMR; P05003; -.
DR STRING; 9796.ENSECAP00000042726; -.
DR PaxDb; P05003; -.
DR Ensembl; ENSECAT00000055018; ENSECAP00000042726; ENSECAG00000031604.
DR GeneID; 100629951; -.
DR KEGG; ecb:100629951; -.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; P05003; -.
DR OMA; CAWERIQ; -.
DR OrthoDB; 1358010at2759; -.
DR TreeFam; TF336177; -.
DR Proteomes; UP000002281; Chromosome 23.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT CHAIN 24..184
FT /note="Interferon alpha-1"
FT /id="PRO_0000016371"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 20808 MW; 9E860B8CD05C83E6 CRC64;
MALPVSLLMA LVVLSCHSIC SLGCDLPHTH SLGNTRVLML LGQMRRISPF SCLKDRNDFG
FPQEVFDGNQ FRKPQAISAV HETIQQIFHL FSTDGSSAAW DESLLDKLYT GLYQQLTELE
ACLSQEVGVE ETPLMNEDSL LAVRRYFQRI ALYLQEKKYS PCAWEIVRAE IMRSFSSSTN
LPQS