ID   IFNA1_PIG               Reviewed;         189 AA.
AC   P49879;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Interferon alpha-1;
DE            Short=IFN-alpha-1;
DE   Flags: Precursor;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Domestica; TISSUE=Liver;
RX   PubMed=1800582; DOI=10.1089/jir.1991.11.341;
RA   Lefevre F., la Bonnardiere C., Mege D.;
RT   "The porcine family of interferon-omega: cloning, structural analysis, and
RT   functional studies of five related genes.";
RL   J. Interferon Res. 11:341-350(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2945869; DOI=10.1089/jir.1986.6.349;
RA   Lefevre F., la Bonnardiere C.;
RT   "Molecular cloning and sequencing of a gene encoding biologically active
RT   porcine alpha-interferon.";
RL   J. Interferon Res. 6:349-360(1986).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; X57191; CAA40477.1; -; Genomic_DNA.
DR   EMBL; M28623; AAA31053.1; -; Genomic_DNA.
DR   PIR; S23709; S23709.
DR   AlphaFoldDB; P49879; -.
DR   SMR; P49879; -.
DR   STRING; 9823.ENSSSCP00000028605; -.
DR   PaxDb; P49879; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..189
FT                   /note="Interferon alpha-1"
FT                   /id="PRO_0000016395"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21434 MW;  8C8BEA8DEAAE3334 CRC64;
     MAPTSAFLTA LVLLSCNAIC SLGCDLPQTH SLAHTRALRL LAQMRRISPF SCLDHRRDFG
     SPHEAFGGNQ VQKAQAMALV HEMLQQTFQL FSTEGSAAAW NESLLHQFYT GLDQQLRDLE
     ACVMQEAGLE GTPLLEEDSI RAVRKYFHRL TLYLQEKSYS PCAWEIVRAE VMRSFSSSRN
     LQDRLRKKE