IFNA2_HORSE
ID IFNA2_HORSE Reviewed; 184 AA.
AC P05004;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Interferon alpha-2;
DE Flags: Precursor;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=3022999; DOI=10.1089/dna.1986.5.345;
RA Himmler A., Hauptmann R., Adolf G.R., Swetly P.;
RT "Molecular cloning and expression in Escherichia coli of equine type I
RT interferons.";
RL DNA 5:345-356(1986).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC {ECO:0000269|PubMed:3022999}.
CC -!- SUBUNIT: Interacts with IFNAR2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M14541; AAA30950.1; -; Genomic_DNA.
DR PIR; B24912; IVHOA2.
DR AlphaFoldDB; P05004; -.
DR SMR; P05004; -.
DR STRING; 9796.ENSECAP00000026656; -.
DR PaxDb; P05004; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT CHAIN 24..184
FT /note="Interferon alpha-2"
FT /id="PRO_0000016372"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 20877 MW; FC15DC7D811C68EC CRC64;
MALPFSLLMA LVVLSCHSSC SLGCDLPHTH SLGNTRVLML LGQMRRISPF SCLKDRNDFG
FPQEVFDGNQ FRKPQAISAV HETIQQIFHL FSTDGSSAAW DESLLDKLYT GLYQQLTELE
ACLSQEVGVE ETPLMNEDSL LAVRRYFQRI ALYLQEKKYS PCAWEIVRAE IMRCFSSSTN
LQQS