IFNA7_MOUSE
ID IFNA7_MOUSE Reviewed; 190 AA.
AC P06799;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Interferon alpha-7;
DE Short=IFN-alpha-7;
DE Flags: Precursor;
GN Name=Ifna7; Synonyms=Ifa7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3017340; DOI=10.1016/s0006-291x(86)80571-x;
RA Dion M., Vodjdani G., Doly J.;
RT "Sequence and expression of a novel murine interferon alpha gene
RT -- homology with enhancer elements in the regulatory region of the gene.";
RL Biochem. Biophys. Res. Commun. 138:826-834(1986).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M13710; AAA37888.1; -; Genomic_DNA.
DR PIR; I49772; I49772.
DR AlphaFoldDB; P06799; -.
DR SMR; P06799; -.
DR GlyGen; P06799; 1 site.
DR PRIDE; P06799; -.
DR MGI; MGI:107661; Ifna7.
DR InParanoid; P06799; -.
DR PhylomeDB; P06799; -.
DR Reactome; R-MMU-909733; Interferon alpha/beta signaling.
DR Reactome; R-MMU-912694; Regulation of IFNA/IFNB signaling.
DR PRO; PR:P06799; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P06799; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT CHAIN 24..190
FT /note="Interferon alpha-7"
FT /id="PRO_0000016380"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 190 AA; 21603 MW; B7A30A9F795CFDAB CRC64;
MARLCAFLMV LAVMSYWPTC CLGCDLPQTH NLRNKRALTL LVKMRRLSPL SCLKDRKDFG
FPQAKVDAQQ IQEAQAIPVL SELTQQILNI FTSKDSSAAW NATLLDSVCN DLHQQLNDLQ
GCLMQEVGVQ ELSLTQEDSL LAVRKYFHRI TVFLREKKHS PCAWEVVRAE IWRALSSSAN
LLARLSEKKE
