ID   IFNA9_MOUSE             Reviewed;         190 AA.
AC   P09235;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 157.
DE   RecName: Full=Interferon alpha-9;
DE            Short=IFN-alpha-9;
DE   Flags: Precursor;
GN   Name=Ifna9; Synonyms=Ifa9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3758677; DOI=10.1016/0378-1119(86)90014-4;
RA   Seif I., Demaeyer-Guignard J.;
RT   "Structure and expression of a new murine interferon-alpha gene: MuIFN-
RT   alpha I9.";
RL   Gene 43:111-121(1986).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M13660; AAA37886.1; -; Genomic_DNA.
DR   CCDS; CCDS18321.1; -.
DR   PIR; A24401; A24401.
DR   RefSeq; NP_034637.1; NM_010507.1.
DR   AlphaFoldDB; P09235; -.
DR   SMR; P09235; -.
DR   STRING; 10090.ENSMUSP00000099871; -.
DR   GlyGen; P09235; 1 site.
DR   PaxDb; P09235; -.
DR   PRIDE; P09235; -.
DR   DNASU; 15972; -.
DR   Ensembl; ENSMUST00000102807; ENSMUSP00000099871; ENSMUSG00000095270.
DR   GeneID; 15972; -.
DR   KEGG; mmu:15972; -.
DR   UCSC; uc008tnc.1; mouse.
DR   CTD; 15972; -.
DR   MGI; MGI:107659; Ifna9.
DR   VEuPathDB; HostDB:ENSMUSG00000095270; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_0_0_1; -.
DR   InParanoid; P09235; -.
DR   OMA; TETHLMY; -.
DR   OrthoDB; 1358010at2759; -.
DR   PhylomeDB; P09235; -.
DR   TreeFam; TF336177; -.
DR   Reactome; R-MMU-909733; Interferon alpha/beta signaling.
DR   Reactome; R-MMU-912694; Regulation of IFNA/IFNB signaling.
DR   BioGRID-ORCS; 15972; 4 hits in 72 CRISPR screens.
DR   PRO; PR:P09235; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; P09235; protein.
DR   Bgee; ENSMUSG00000095270; Expressed in telencephalic nucleus and 15 other tissues.
DR   Genevisible; P09235; MM.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IDA:MGI.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IDA:MGI.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..190
FT                   /note="Interferon alpha-9"
FT                   /id="PRO_0000016382"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   190 AA;  21684 MW;  CF6D8FEC621D6CDA CRC64;
     MARPFAFLMV LVVISYWSTC SLGCDLPQTH NLRNKKILTL LAQMRRLSPL SCLKDRKDFG
     FPQEKVDAQQ IQEAQAIPVL SELTQQILTL FTSKDSSAAW NATLLDSFCT GLHQLLNDLQ
     GCLMQLVGMK ELPLTQEDSQ LAMKKYFHRI TVYLREKKHS PCAWEVVRAE VWRALSSSVN
     LLARLSEEKE