IFNAB_MOUSE
ID IFNAB_MOUSE Reviewed; 190 AA.
AC Q61716; Q810G4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Interferon alpha-11;
DE Short=IFN-alpha-11;
DE AltName: Full=Limitin;
DE Flags: Precursor;
GN Name=Ifna11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1655578; DOI=10.1016/0378-1119(91)90249-b;
RA Coulombel C., Vodjdani G., Doly J.;
RT "Isolation and characterization of a novel interferon-alpha-encoding gene,
RT IFN-alpha 11, within a murine IFN cluster.";
RL Gene 104:187-195(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, AND FUNCTION.
RC STRAIN=C57BL/6J;
RX PubMed=15254193; DOI=10.1128/jvi.78.15.8219-8228.2004;
RA van Pesch V., Lanaya H., Renauld J.C., Michiels T.;
RT "Characterization of the murine alpha interferon gene family.";
RL J. Virol. 78:8219-8228(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=22912583; DOI=10.1371/journal.ppat.1002868;
RA Gibbert K., Joedicke J.J., Meryk A., Trilling M., Francois S., Duppach J.,
RA Kraft A., Lang K.S., Dittmer U.;
RT "Interferon-alpha subtype 11 activates NK cells and enables control of
RT retroviral infection.";
RL PLoS Pathog. 8:E1002868-E1002868(2012).
CC -!- FUNCTION: Has antiviral and antiproliferative activities
CC (PubMed:15254193). Produced by macrophages and stimulates the
CC production of two enzymes: a protein kinase and an oligoadenylate
CC synthetase (By similarity). During viral infection, mediates antiviral
CC effect, either directly by inducing interferon-stimulated genes, either
CC indirectly through stimulation of natural killer cells enabling them to
CC control viral replication (PubMed:22912583). {ECO:0000250,
CC ECO:0000269|PubMed:15254193, ECO:0000269|PubMed:22912583}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- PTM: N-glycosylated (PubMed:15254193). {ECO:0000269|PubMed:15254193}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M68944; AAA37883.1; -; Genomic_DNA.
DR EMBL; AY225954; AAO63596.1; -; Genomic_DNA.
DR EMBL; AL928605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116870; AAI16871.1; -; mRNA.
DR EMBL; BC116872; AAI16873.1; -; mRNA.
DR CCDS; CCDS38810.1; -.
DR PIR; JH0468; JH0468.
DR RefSeq; NP_032359.2; NM_008333.2.
DR AlphaFoldDB; Q61716; -.
DR SMR; Q61716; -.
DR STRING; 10090.ENSMUSP00000127921; -.
DR GlyGen; Q61716; 1 site.
DR iPTMnet; Q61716; -.
DR PhosphoSitePlus; Q61716; -.
DR PaxDb; Q61716; -.
DR PRIDE; Q61716; -.
DR DNASU; 15964; -.
DR Ensembl; ENSMUST00000170428; ENSMUSP00000127921; ENSMUSG00000100549.
DR GeneID; 15964; -.
DR KEGG; mmu:15964; -.
DR UCSC; uc008tny.2; mouse.
DR CTD; 15964; -.
DR MGI; MGI:109210; Ifna11.
DR VEuPathDB; HostDB:ENSMUSG00000100549; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR InParanoid; Q61716; -.
DR OMA; RKYSPCA; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q61716; -.
DR TreeFam; TF336177; -.
DR Reactome; R-MMU-909733; Interferon alpha/beta signaling.
DR Reactome; R-MMU-912694; Regulation of IFNA/IFNB signaling.
DR BioGRID-ORCS; 15964; 1 hit in 40 CRISPR screens.
DR PRO; PR:Q61716; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q61716; protein.
DR Bgee; ENSMUSG00000100549; Expressed in submandibular gland and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0030101; P:natural killer cell activation; IDA:UniProtKB.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..190
FT /note="Interferon alpha-11"
FT /id="PRO_0000317634"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
FT CONFLICT 48
FT /note="T -> S (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="K -> Q (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 72..76
FT /note="QKAQS -> KKAQA (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 92..95
FT /note="ASKD -> TSKA (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> P (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="S -> A (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="R -> S (in Ref. 4; AAI16871/AAI16873 and 1;
FT AAA37883)"
FT /evidence="ECO:0000305"
FT CONFLICT 179..186
FT /note="ANVLGRLR -> VNLLARLS (in Ref. 4; AAI16871/AAI16873
FT and 1; AAA37883)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 21736 MW; 87BB8781552A94D1 CRC64;
MARLCAFLMI LIVMSYWSTC SLGCDLPHTY NLRNKRALKV LAQMRRLTPL SCLKDRKDFG
FPLEKVDAQQ IQKAQSIPVL RDLTQQILNL FASKDSSAAW NATLLDSFCN DLHQQLNDLQ
GCLMQQVGVQ ESPLTQEDSL LAVRIYFHRI TVFLREKKHS PCAWEVVRAE VWRALSSSAN
VLGRLREEKA
