IFNAC_BOVIN
ID IFNAC_BOVIN Reviewed; 189 AA.
AC P05009;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Interferon alpha-C;
DE Flags: Precursor;
GN Name=IFNAC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3886658; DOI=10.1016/s0021-9258(18)89050-0;
RA Velan B., Cohen S., Grosfeld H., Leitner M., Shafferman A.;
RT "Bovine interferon alpha genes. Structure and expression.";
RL J. Biol. Chem. 260:5498-5504(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3020355; DOI=10.1016/0076-6879(86)19066-5;
RA Velan B., Cohen S., Grosfeld H., Shafferman A.;
RT "Isolation of bovine IFN-alpha genes and their expression in bacteria.";
RL Methods Enzymol. 119:464-474(1986).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M10954; AAA30575.1; -; Genomic_DNA.
DR EMBL; M29314; AAA30572.1; -; mRNA.
DR PIR; C26028; IVBOIC.
DR RefSeq; NP_776510.1; NM_174085.1.
DR AlphaFoldDB; P05009; -.
DR SMR; P05009; -.
DR PaxDb; P05009; -.
DR GeneID; 281236; -.
DR KEGG; bta:281236; -.
DR CTD; 281236; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR InParanoid; P05009; -.
DR OrthoDB; 1358010at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT CHAIN 24..189
FT /note="Interferon alpha-C"
FT /id="PRO_0000016387"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 189 AA; 21572 MW; 32F2C590D647BE8C CRC64;
MAPAWSFRLA LLLLSCNAIC SLGCHLPHTH SLANRRVLML LGQLRRVSPS SCLQDRNDFA
FPQEALGGSQ LQKAQAISVL HEVTQHTFQL FSTEGSATMW DESLLDKLRD ALDQQLTDLQ
FCLRQEEELQ GAPLLKEDSS LAVRKYFHRL TLYLQEKRHS PCAWEVVRAQ VMRAFSSSTN
LQESFRRKD