IFNAC_MOUSE
ID IFNAC_MOUSE Reviewed; 189 AA.
AC Q80SS5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Interferon alpha-12;
DE Short=IFN-alpha-12;
DE Flags: Precursor;
GN Name=Ifna12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15254193; DOI=10.1128/jvi.78.15.8219-8228.2004;
RA van Pesch V., Lanaya H., Renauld J.C., Michiels T.;
RT "Characterization of the murine alpha interferon gene family.";
RL J. Virol. 78:8219-8228(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15233997; DOI=10.1016/j.ygeno.2004.03.003;
RA Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
RT "Characterization of the type I interferon locus and identification of
RT novel genes.";
RL Genomics 84:331-345(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC Interferon stimulates the production of two enzymes: a protein kinase
CC and an oligoadenylate synthetase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY190046; AAO38687.1; -; mRNA.
DR EMBL; AY225951; AAO63593.1; -; Genomic_DNA.
DR EMBL; AL772394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104352; AAI04353.1; -; mRNA.
DR EMBL; BC104353; AAI04354.1; -; mRNA.
DR CCDS; CCDS18322.1; -.
DR RefSeq; NP_796335.1; NM_177361.2.
DR AlphaFoldDB; Q80SS5; -.
DR SMR; Q80SS5; -.
DR BioGRID; 232416; 1.
DR IntAct; Q80SS5; 1.
DR STRING; 10090.ENSMUSP00000099870; -.
DR GlyGen; Q80SS5; 1 site.
DR PaxDb; Q80SS5; -.
DR PRIDE; Q80SS5; -.
DR DNASU; 242519; -.
DR Ensembl; ENSMUST00000102806; ENSMUSP00000099870; ENSMUSG00000073811.
DR GeneID; 242519; -.
DR KEGG; mmu:242519; -.
DR UCSC; uc008tnd.1; mouse.
DR CTD; 242519; -.
DR MGI; MGI:2676324; Ifna12.
DR VEuPathDB; HostDB:ENSMUSG00000073811; -.
DR eggNOG; ENOG502SQAC; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_0_0_1; -.
DR InParanoid; Q80SS5; -.
DR OMA; CAWERIQ; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q80SS5; -.
DR TreeFam; TF336177; -.
DR Reactome; R-MMU-909733; Interferon alpha/beta signaling.
DR Reactome; R-MMU-912694; Regulation of IFNA/IFNB signaling.
DR BioGRID-ORCS; 242519; 3 hits in 35 CRISPR screens.
DR PRO; PR:Q80SS5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80SS5; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..189
FT /note="Interferon alpha-12"
FT /id="PRO_5000090450"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 189 AA; 21752 MW; F9032BF542021BD1 CRC64;
MARLCAFLMT LLVMSYWSTC SLGCDLPQTH NLRNKRALTL LAQMRRLSPL SCLKDRKNFR
FPQEKVDAQQ IKKAQVIPVL SELTQQILTL FTSKDSSAAW NTTLLDSFCN DLHQQLNDLQ
GCLMQQVGVQ EPPLTQEDSL LAVRKYFHRI TVYLREKKHS PCAWEVVRAE VWRTLSSSAK
LLARLSEKE
