ID   IFNAH_BOVIN             Reviewed;         189 AA.
AC   P49878;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Interferon alpha-H;
DE   AltName: Full=IFN-alpha8;
DE   Flags: Precursor;
GN   Name=IFNAH; Synonyms=IFNA8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=8662077; DOI=10.1007/bf02660063;
RA   Chaplin P.J., Parsons K.R., Collins B.A.;
RT   "The cloning of cattle interferon-A subtypes isolated from the gut
RT   epithelium of rotavirus-infected calves.";
RL   Immunogenetics 44:143-145(1996).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; X93089; CAA63638.1; -; mRNA.
DR   RefSeq; NP_001165512.1; NM_001172041.1.
DR   AlphaFoldDB; P49878; -.
DR   SMR; P49878; -.
DR   STRING; 9913.ENSBTAP00000034345; -.
DR   PaxDb; P49878; -.
DR   PRIDE; P49878; -.
DR   GeneID; 100329207; -.
DR   KEGG; bta:100329207; -.
DR   CTD; 100329207; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   InParanoid; P49878; -.
DR   OrthoDB; 1358010at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..189
FT                   /note="Interferon alpha-H"
FT                   /id="PRO_0000016391"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   189 AA;  21479 MW;  B98F8FAC87EB5C82 CRC64;
     MAPAWSFLLA LLLLSCNAIC SLGCHLPHTH SLPNRRVLTL LRQLRRVSPS SCLQDRNDFA
     FPQEALGGSQ LQKAQAISVL HEVTQHTFQL FSTEGSAAAW DESLLDKLRA ALDQQLTDLQ
     ACLRQEEGLR GAPLLKEDAS LAVRKYFHRL TLYLREKRHN PCAWEVVRAE VMRAFSSSTN
     LQERFRRKD