ID   IFNA_FELCA              Reviewed;         194 AA.
AC   P35849; Q28831;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Interferon alpha;
DE            Short=IFN-alpha;
DE   Flags: Precursor;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1377975; DOI=10.1271/bbb.56.211;
RA   Nakamura N., Sudo T., Matsuda S., Yanai A.;
RT   "Molecular cloning of feline interferon cDNA by direct expression.";
RL   Biosci. Biotechnol. Biochem. 56:211-214(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-193.
RX   PubMed=7685640; DOI=10.1292/jvms.55.251;
RA   Ueda Y., Sakurai T., Yanai A.;
RT   "Homogeneous production of feline interferon in silkworm by replacing
RT   single amino acid code in signal peptide region in recombinant baculovirus
RT   and characterization of the product.";
RL   J. Vet. Med. Sci. 55:251-258(1993).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PHARMACEUTICAL: Available under the names Virbagen Omega and Intercat.
CC       Used in veterinary medicine to treat canine parvovirus, feline leukemia
CC       virus and feline immunodeficiency virus infections. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; S62636; AAB27160.2; -; mRNA.
DR   PIR; JS0664; JS0664.
DR   RefSeq; NP_001009197.2; NM_001009197.2.
DR   AlphaFoldDB; P35849; -.
DR   SMR; P35849; -.
DR   STRING; 9685.ENSFCAP00000016988; -.
DR   Ensembl; ENSFCAT00000038547; ENSFCAP00000032900; ENSFCAG00000046651.
DR   GeneID; 493653; -.
DR   KEGG; fca:493653; -.
DR   CTD; 3444; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_0_0_1; -.
DR   OMA; LDNRKTM; -.
DR   OrthoDB; 1358010at2759; -.
DR   Proteomes; UP000011712; Chromosome D4.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Pharmaceutical;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..194
FT                   /note="Interferon alpha"
FT                   /id="PRO_0000016394"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        24..123
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..166
FT                   /evidence="ECO:0000250"
FT   CONFLICT        21
FT                   /note="S -> V (in Ref. 2; AAB27160)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   194 AA;  21892 MW;  D10E916E3755BFEF CRC64;
     MALPSSFLVA LVALGCNSVC SLGCDLPQTH GLLNRRALTL LGQMRRLPAS SCQKDRNDFA
     FPQDVFGGDQ SHKAQALSVV HVTNQKIFHF FCTEASSSAA WNTTLLEEFC TGLDRQLTRL
     EACVLQEVEE GEAPLTNEDI HPEDSILRNY FQRLSLYLQE KKYSPCAWEI VRAEIMRSLY
     YSSTALQKRL RSEK