ID   IFNA_MELGA              Reviewed;         192 AA.
AC   P51527;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Interferon;
DE            Short=TkIFN;
DE   Flags: Precursor;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=Nicholas;
RX   PubMed=7494342; DOI=10.1128/jvi.69.12.8159-8163.1995;
RA   Suresh M., Karaca K., Foster D., Sharma J.M.;
RT   "Molecular and functional characterization of turkey interferon.";
RL   J. Virol. 69:8159-8163(1995).
CC   -!- FUNCTION: Has antiviral activities. {ECO:0000269|PubMed:7494342}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; U28140; AAB40029.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51527; -.
DR   SMR; P51527; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005132; F:type I interferon receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..192
FT                   /note="Interferon"
FT                   /id="PRO_0000016431"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        31..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..154
FT                   /evidence="ECO:0000255"
FT   DISULFID        67..167
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   192 AA;  21884 MW;  9ED81EF2DC4FF2C3 CRC64;
     MAVPASPQHP RGYGILLLTL LMKALAAAAA CNHLRPQDAT FSRDSLQLLR DMAPSPPQPC
     PQHNAPCSFN DTVLDTNNTQ QADKTTHNIL QHLFKILSGP TTPAHWIDSQ RQSLLNQIQR
     YAQHLEQCLA DSHTRSRTRW PHNPHLTINK HFSCLHAFLH DNDYSACAWD HVRLRARAWL
     LHIHDLVRNT RT