ID   IFNB1_BOVIN             Reviewed;         186 AA.
AC   P01578;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Interferon beta-1;
DE   Flags: Precursor;
GN   Name=IFNB1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Leung D.W., Capon D.J., Goeddel D.V.;
RT   "The structure and bacterial expression of three distinct bovine
RT   interferon-beta genes.";
RL   Biotechnology (N.Y.) 2:458-464(1984).
CC   -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M15477; AAA30579.1; -; Genomic_DNA.
DR   PIR; A01842; IVBOB1.
DR   RefSeq; NP_776775.1; NM_174350.1.
DR   AlphaFoldDB; P01578; -.
DR   SMR; P01578; -.
DR   STRING; 9913.ENSBTAP00000055343; -.
DR   PaxDb; P01578; -.
DR   GeneID; 281845; -.
DR   KEGG; bta:281845; -.
DR   CTD; 3456; -.
DR   eggNOG; ENOG502SQGR; Eukaryota.
DR   InParanoid; P01578; -.
DR   OrthoDB; 1358010at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005132; F:type I interferon receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..186
FT                   /note="Interferon beta-1"
FT                   /id="PRO_0000016396"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..161
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  22195 MW;  F9060C07EA415B9C CRC64;
     MTYRCLLQMV LLLCFSTTAL SRSYSLLRFQ QRQSLKECQK LLGQLPSTSQ HCLEARMDFQ
     MPEEMKQEQQ FQKEDAILVM YEVLQHIFGI LTRDFSSTGW SETIIEDLLK ELYWQMNRLQ
     PIQKEIMQKQ NSTTEDTIVP HLGKYYFNLM QYLESKEYDR CAWTVVQVQI LTNVSFLMRL
     TGYVRD