IFNB2_BOVIN
ID IFNB2_BOVIN Reviewed; 186 AA.
AC P01576;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Interferon beta-2;
DE Flags: Precursor;
GN Name=IFNB2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Leung D.W., Capon D.J., Goeddel D.V.;
RT "The structure and bacterial expression of three distinct bovine
RT interferon-beta genes.";
RL Biotechnology (N.Y.) 2:458-464(1984).
CC -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M15478; AAA30580.1; -; Genomic_DNA.
DR PIR; A01840; IVBOB2.
DR RefSeq; NP_001015617.1; NM_001015617.1.
DR AlphaFoldDB; P01576; -.
DR SMR; P01576; -.
DR STRING; 9913.ENSBTAP00000045034; -.
DR PaxDb; P01576; -.
DR Ensembl; ENSBTAT00000047871; ENSBTAP00000045034; ENSBTAG00000054945.
DR GeneID; 517016; -.
DR KEGG; bta:517016; -.
DR VEuPathDB; HostDB:ENSBTAG00000054945; -.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; P01576; -.
DR OMA; ELYEQMN; -.
DR OrthoDB; 1358010at2759; -.
DR TreeFam; TF336177; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000054945; Expressed in thymus and 57 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR InterPro; IPR015588; Interferon_beta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT CHAIN 22..186
FT /note="Interferon beta-2"
FT /id="PRO_0000016397"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52..161
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 22319 MW; D9F257C6E3250480 CRC64;
MTHRCLLQMV LLLCFSTTAL SRSYSLLRFQ QRRSLALCQK LLRQLPSTPQ HCLEARMDFQ
MPEEMKQAQQ FQKEDAILVI YEMLQQIFNI LTRDFSSTGW SETIIEDLLE ELYEQMNHLE
PIQKEIMQKQ NSTMGDTTVL HLRKYYFNLV QYLKSKEYNR CAWTVVRVQI LRNFSFLTRL
TGYLRE
