ID   IFNB3_BOVIN             Reviewed;         186 AA.
AC   P01577;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Interferon beta-3;
DE   Flags: Precursor;
GN   Name=IFNB3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Leung D.W., Capon D.J., Goeddel D.V.;
RT   "The structure and bacterial expression of three distinct bovine
RT   interferon-beta genes.";
RL   Biotechnology (N.Y.) 2:458-464(1984).
CC   -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M15479; AAA30581.1; -; Genomic_DNA.
DR   PIR; A01841; IVBOB3.
DR   RefSeq; NP_001107769.1; NM_001114297.1.
DR   AlphaFoldDB; P01577; -.
DR   SMR; P01577; -.
DR   STRING; 9913.ENSBTAP00000056510; -.
DR   PaxDb; P01577; -.
DR   PRIDE; P01577; -.
DR   GeneID; 618946; -.
DR   KEGG; bta:618946; -.
DR   CTD; 618946; -.
DR   eggNOG; ENOG502SQGR; Eukaryota.
DR   InParanoid; P01577; -.
DR   OrthoDB; 1358010at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..186
FT                   /note="Interferon beta-3"
FT                   /id="PRO_0000016398"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..161
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  22060 MW;  1D10111EBEE1A65D CRC64;
     MTYRCLLPMV LLLCFSTTAL SRSYSLLRFQ QRRSAEVCQK LLGQLHSTPQ HCLEAKMDFQ
     VPEEMNQAQQ FRKEDAILVI YEMLQQIFNI LTRDFSSTGW SETIIEDLLV ELYGQMNRLQ
     PIQKEIMQEQ NFTMGDTTVL HLKKYYFNLV QYLESKEYNR CAWTVVRVQI LTNFSFLMRL
     TASLRD