IFNB_CHICK
ID IFNB_CHICK Reviewed; 203 AA.
AC Q90873; Q4Z8K4;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Interferon type B;
DE Short=IFN-beta;
DE Flags: Precursor;
GN Name=IFNB; Synonyms=IFN2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=White leghorn; TISSUE=Spleen;
RX PubMed=8631799; DOI=10.1074/jbc.271.13.7635;
RA Sick C., Schultz U., Staeheli P.;
RT "A family of genes coding for two serologically distinct chicken
RT interferons.";
RL J. Biol. Chem. 271:7635-7639(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Han C.-L., Wang M., Gao F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has antiviral activities.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; X92479; CAA63217.1; -; Genomic_DNA.
DR EMBL; AY974089; AAX83679.1; -; mRNA.
DR RefSeq; NP_001020007.1; NM_001024836.1.
DR AlphaFoldDB; Q90873; -.
DR SMR; Q90873; -.
DR STRING; 9031.ENSGALP00000038687; -.
DR PaxDb; Q90873; -.
DR Ensembl; ENSGALT00000039477; ENSGALP00000038687; ENSGALG00000005759.
DR GeneID; 554219; -.
DR KEGG; gga:554219; -.
DR CTD; 3467; -.
DR VEuPathDB; HostDB:geneid_554219; -.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; Q90873; -.
DR OMA; CHHLRTH; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q90873; -.
DR TreeFam; TF336177; -.
DR Reactome; R-GGA-909733; Interferon alpha/beta signaling.
DR Reactome; R-GGA-912694; Regulation of IFNA/IFNB signaling.
DR PRO; PR:Q90873; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000005759; Expressed in skeletal muscle tissue and 3 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:AgBase.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0045918; P:negative regulation of cytolysis; IDA:AgBase.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:AgBase.
DR GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IEP:AgBase.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR InterPro; IPR015588; Interferon_beta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR Pfam; PF00143; Interferon; 1.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..203
FT /note="Interferon type B"
FT /id="PRO_0000016430"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..125
FT /evidence="ECO:0000250"
FT DISULFID 57..164
FT /evidence="ECO:0000255"
SQ SEQUENCE 203 AA; 23686 MW; E9D84FEC7803FE7A CRC64;
MTANHQSPGM HSILLLLLLP ALTTTFSCNH LRHQDANFSW KSLQLLQNTA PPPPQPCPQQ
DVTFPFPETL LKSKDKKQAA ITTLRILQHL FNMLSSPHTP KHWIDRTRHS LLNQIQHYIH
HLEQCFVNQG TRSQRRGPRN AHLSINKYFR SIHNFLQHNN YSACTWDHVR LQARDCFRHV
DTLIQWMKSR APLTASSKRL NTQ
