ID   IFNB_HORSE              Reviewed;         186 AA.
AC   P05012;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Interferon beta;
DE            Short=IFN-beta;
DE   Flags: Precursor;
GN   Name=IFNB1; Synonyms=IFNB;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3022999; DOI=10.1089/dna.1986.5.345;
RA   Himmler A., Hauptmann R., Adolf G.R., Swetly P.;
RT   "Molecular cloning and expression in Escherichia coli of equine type I
RT   interferons.";
RL   DNA 5:345-356(1986).
CC   -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC   -!- SUBUNIT: Monomer. Signals mostly via binding to a IFNAR1-IFNAR2
CC       heterodimeric receptor, but can also function with IFNAR1 alone and
CC       independently of Jak-STAT pathways (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; M14546; AAA30954.1; -; Genomic_DNA.
DR   PIR; G24912; IVHOBI.
DR   RefSeq; NP_001092910.1; NM_001099440.1.
DR   AlphaFoldDB; P05012; -.
DR   SMR; P05012; -.
DR   STRING; 9796.ENSECAP00000004620; -.
DR   PaxDb; P05012; -.
DR   PRIDE; P05012; -.
DR   Ensembl; ENSECAT00000006501; ENSECAP00000004620; ENSECAG00000006484.
DR   GeneID; 100052545; -.
DR   KEGG; ecb:100052545; -.
DR   CTD; 3456; -.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_1_0_1; -.
DR   InParanoid; P05012; -.
DR   OMA; HWQKEHL; -.
DR   OrthoDB; 1358010at2759; -.
DR   TreeFam; TF336177; -.
DR   Proteomes; UP000002281; Chromosome 23.
DR   Bgee; ENSECAG00000006484; Expressed in trophectoderm.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..186
FT                   /note="Interferon beta"
FT                   /id="PRO_0000016401"
FT   MOD_RES         24
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P70499"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        136
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..161
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  21882 MW;  AE9F3ADFC006EE6C CRC64;
     MTYRWILPMA LLLCFSTTAL SVNYDLLRSQ LRSSNSACLM LLRQLNGAPQ RCPEDTMNFQ
     VPEEIEQAQQ FQKEDAALVI YEMLQHTWRI FRRNFASTGW NETIVKNLLV EVHLQMDRLE
     TNLEEIMEEE SSTWGNTTIL RLKKYYGRIS QYLKAKKYSH CAWTVVQAEM LRNLAFLNGL
     TDYLQN