ID   IFNB_MACFA              Reviewed;         187 AA.
AC   O77812;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Interferon beta;
DE            Short=IFN-beta;
DE   Flags: Precursor;
GN   Name=IFNB1; Synonyms=IFNB;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10048395; DOI=10.1089/10430349950018878;
RA   Matheux F., Le Grand R., Rousseau V., De Maeyer E., Dormont D., Lauret E.;
RT   "Macaque lymphocytes transduced by a constitutively expressed interferon
RT   beta gene display an enhanced resistance to SIVmac251 infection.";
RL   Hum. Gene Ther. 10:429-440(1999).
CC   -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC   -!- SUBUNIT: Monomer. Signals mostly via binding to a IFNAR1-IFNAR2
CC       heterodimeric receptor, but can also function with IFNAR1 alone and
CC       independently of Jak-STAT pathways (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; AJ011909; CAA09862.1; -; Genomic_DNA.
DR   AlphaFoldDB; O77812; -.
DR   SMR; O77812; -.
DR   STRING; 9541.XP_005581693.1; -.
DR   eggNOG; ENOG502SQGR; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005132; F:type I interferon receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Phosphoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..187
FT                   /note="Interferon beta"
FT                   /id="PRO_0000016402"
FT   MOD_RES         24
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P70499"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  22266 MW;  376AEF73332B7807 CRC64;
     MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSSFQCQK LLWQLNGRLE YCLKDRMNFD
     IPEEIKQPQQ FQKEDAALTI YEMLQNIYAI FRQDLSSTGW NETIVENLLA NVYHQIDHLK
     TILEEKLEKE DFTRGKFVSS LHLKRYYGRI LHYLKAKEYS HCAWTIVRVE ILRNFFFINK
     LTGYLRN