IFNB_RAT
ID IFNB_RAT Reviewed; 184 AA.
AC P70499;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Interferon beta;
DE Short=IFN-beta;
DE Flags: Precursor;
GN Name=Ifnb1; Synonyms=Ifnb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar; TISSUE=Liver;
RX PubMed=9126338; DOI=10.1006/bbrc.1997.6359;
RA Yokoyama S., Ohishi N., Shamoto M., Watanabe Y., Yagi K.;
RT "Isolation and expression of rat interferon beta gene and growth-inhibitory
RT effect of its expression on rat glioma cells.";
RL Biochem. Biophys. Res. Commun. 232:698-701(1997).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
CC -!- FUNCTION: Has antiviral, antibacterial and anticancer activities.
CC -!- SUBUNIT: Monomer. Signals mostly via binding to a IFNAR1-IFNAR2
CC heterodimeric receptor, but can also function with IFNAR1 alone and
CC independently of Jak-STAT pathways (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: This beta interferon does not have a disulfide bond.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; D87919; BAA13502.1; -; Genomic_DNA.
DR PIR; JC5424; JC5424.
DR RefSeq; NP_062000.1; NM_019127.1.
DR AlphaFoldDB; P70499; -.
DR SMR; P70499; -.
DR STRING; 10116.ENSRNOP00000008225; -.
DR GlyGen; P70499; 4 sites.
DR iPTMnet; P70499; -.
DR PhosphoSitePlus; P70499; -.
DR PaxDb; P70499; -.
DR Ensembl; ENSRNOT00000008224; ENSRNOP00000008225; ENSRNOG00000006268.
DR GeneID; 24481; -.
DR KEGG; rno:24481; -.
DR UCSC; RGD:2865; rat.
DR CTD; 3456; -.
DR RGD; 2865; Ifnb1.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; P70499; -.
DR OMA; HWQKEHL; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; P70499; -.
DR TreeFam; TF336177; -.
DR Reactome; R-RNO-909733; Interferon alpha/beta signaling.
DR Reactome; R-RNO-912694; Regulation of IFNA/IFNB signaling.
DR PRO; PR:P70499; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Genevisible; P70499; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0008811; F:chloramphenicol O-acetyltransferase activity; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0005132; F:type I interferon receptor binding; ISO:RGD.
DR GO; GO:0002250; P:adaptive immune response; ISO:RGD.
DR GO; GO:0002312; P:B cell activation involved in immune response; ISO:RGD.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; ISO:RGD.
DR GO; GO:0071549; P:cellular response to dexamethasone stimulus; ISO:RGD.
DR GO; GO:0071359; P:cellular response to dsRNA; ISO:RGD.
DR GO; GO:0035458; P:cellular response to interferon-beta; ISO:RGD.
DR GO; GO:0098586; P:cellular response to virus; ISO:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR GO; GO:0006959; P:humoral immune response; ISO:RGD.
DR GO; GO:0002281; P:macrophage activation involved in immune response; IDA:UniProtKB.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:RGD.
DR GO; GO:0045581; P:negative regulation of T cell differentiation; ISO:RGD.
DR GO; GO:2000552; P:negative regulation of T-helper 2 cell cytokine production; ISO:RGD.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISO:RGD.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0043330; P:response to exogenous dsRNA; ISO:RGD.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0060337; P:type I interferon signaling pathway; ISO:RGD.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR InterPro; IPR015588; Interferon_beta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Phosphoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..184
FT /note="Interferon beta"
FT /id="PRO_0000016404"
FT MOD_RES 24
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:16641100"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 184 AA; 22073 MW; 1D051D29F979ADDE CRC64;
MANRWTLHIA FLLCFSTTAL SIDYKQLQFR QSTSIRTCQK LLRQLNGRLN LSYRTDFKIP
MEVMHPSQME KSYTAFAIQV MLQNVFLVFR SNFSSTGWNE TIVESLLDEL HQQTELLEII
LKEKQEERLT WVTSTTTLGL KSYYWRVQRY LKDKKYNSYA WMVVRAEVFR NFSIILRLNR
NFQN
