ID   IFNB_TACAC              Reviewed;         187 AA.
AC   Q6XZW6;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Interferon beta;
DE            Short=IFN-beta;
DE   Flags: Precursor;
GN   Name=IFNB1; Synonyms=IFNB;
OS   Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked
OS   echidna).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Tachyglossidae; Tachyglossus.
OX   NCBI_TaxID=49271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15061761; DOI=10.1046/j.0818-9641.2004.01230.x;
RA   Harrison G.A., McNicol K.A., Deane E.M.;
RT   "Type I interferon genes from the egg-laying mammal, Tachyglossus aculeatus
RT   (short-beaked echidna).";
RL   Immunol. Cell Biol. 82:112-118(2004).
CC   -!- FUNCTION: Has antiviral and antibacterial activities. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Signals mostly via binding to a IFNAR1-IFNAR2
CC       heterodimeric receptor, but can also function with IFNAR1 alone and
CC       independently of Jak-STAT pathways (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; AY194920; AAP34279.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6XZW6; -.
DR   SMR; Q6XZW6; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Phosphoprotein;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..187
FT                   /note="Interferon beta"
FT                   /id="PRO_0000041829"
FT   MOD_RES         24
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P70499"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  22496 MW;  00A7FAC603EA58E5 CRC64;
     MTSRSLLPFV LSLLLPRIIM AQSYLELYSH QWLNNWKSLH LLNELDGQFP LHCLKESMNF
     KLPAEMLHPH QFQQENATEA IHDLLQQIFN IFSRNHSQTG WDEAIVEKFL HGVHQEMVWL
     ELFLEEEMGW ENSTLRRDIS LHIKSYFKRM MDYLKGRNYS SCAWEVIRME TKRSCLVIYR
     LTRKLKK