IFNE_HUMAN
ID IFNE_HUMAN Reviewed; 208 AA.
AC Q86WN2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Interferon epsilon;
DE Short=IFN-epsilon;
DE AltName: Full=Interferon epsilon-1;
DE Flags: Precursor;
GN Name=IFNE; Synonyms=IFNE1; ORFNames=UNQ360/PRO655;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15233997; DOI=10.1016/j.ygeno.2004.03.003;
RA Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
RT "Characterization of the type I interferon locus and identification of
RT novel genes.";
RL Genomics 84:331-345(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23449591; DOI=10.1126/science.1233321;
RA Fung K.Y., Mangan N.E., Cumming H., Horvat J.C., Mayall J.R., Stifter S.A.,
RA De Weerd N., Roisman L.C., Rossjohn J., Robertson S.A., Schjenken J.E.,
RA Parker B., Gargett C.E., Nguyen H.P., Carr D.J., Hansbro P.M.,
RA Hertzog P.J.;
RT "Interferon-epsilon protects the female reproductive tract from viral and
RT bacterial infection.";
RL Science 339:1088-1092(2013).
CC -!- FUNCTION: Type I interferon required for maintaining basal levels of
CC IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7
CC and ISG15, in the female reproductive tract. Directly mediates
CC protection against viral and bacterial genital infections (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Endometrium-specific.
CC {ECO:0000269|PubMed:23449591}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in endometrial epithelial cells
CC in proliferative phase of the menstrual cycle. Levels decrease
CC approximately 10-fold in the secretory phase. Virtually undetectable in
CC samples from postmenopausal women. {ECO:0000269|PubMed:23449591}.
CC -!- INDUCTION: By estrogens. {ECO:0000305|PubMed:23449591}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; AY190045; AAO38686.1; -; mRNA.
DR EMBL; AY358570; AAQ88933.1; -; mRNA.
DR EMBL; BC100871; AAI00872.1; -; mRNA.
DR EMBL; BC100872; AAI00873.1; -; mRNA.
DR EMBL; BC100873; AAI00874.1; -; mRNA.
DR CCDS; CCDS34997.1; -.
DR RefSeq; NP_795372.1; NM_176891.4.
DR AlphaFoldDB; Q86WN2; -.
DR SMR; Q86WN2; -.
DR BioGRID; 130722; 31.
DR ComplexPortal; CPX-6008; Interferon epsilon receptor-ligand complex.
DR IntAct; Q86WN2; 9.
DR STRING; 9606.ENSP00000418018; -.
DR GlyGen; Q86WN2; 2 sites.
DR iPTMnet; Q86WN2; -.
DR PhosphoSitePlus; Q86WN2; -.
DR BioMuta; IFNE; -.
DR DMDM; 74727686; -.
DR MassIVE; Q86WN2; -.
DR PaxDb; Q86WN2; -.
DR PeptideAtlas; Q86WN2; -.
DR PRIDE; Q86WN2; -.
DR ProteomicsDB; 70184; -.
DR Antibodypedia; 24882; 147 antibodies from 21 providers.
DR DNASU; 338376; -.
DR Ensembl; ENST00000448696.4; ENSP00000418018.2; ENSG00000184995.7.
DR GeneID; 338376; -.
DR KEGG; hsa:338376; -.
DR MANE-Select; ENST00000448696.4; ENSP00000418018.2; NM_176891.5; NP_795372.1.
DR UCSC; uc003zpg.4; human.
DR CTD; 338376; -.
DR DisGeNET; 338376; -.
DR GeneCards; IFNE; -.
DR HGNC; HGNC:18163; IFNE.
DR HPA; ENSG00000184995; Tissue enhanced (esophagus).
DR MIM; 615223; gene.
DR neXtProt; NX_Q86WN2; -.
DR OpenTargets; ENSG00000184995; -.
DR PharmGKB; PA164720874; -.
DR VEuPathDB; HostDB:ENSG00000184995; -.
DR eggNOG; ENOG502S65R; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; Q86WN2; -.
DR OMA; QQCLPHR; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q86WN2; -.
DR TreeFam; TF336177; -.
DR PathwayCommons; Q86WN2; -.
DR SignaLink; Q86WN2; -.
DR BioGRID-ORCS; 338376; 11 hits in 1058 CRISPR screens.
DR GenomeRNAi; 338376; -.
DR Pharos; Q86WN2; Tbio.
DR PRO; PR:Q86WN2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q86WN2; protein.
DR Bgee; ENSG00000184995; Expressed in stromal cell of endometrium and 59 other tissues.
DR Genevisible; Q86WN2; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0098586; P:cellular response to virus; IC:ComplexPortal.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; ISS:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0060337; P:type I interferon signaling pathway; IC:ComplexPortal.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..208
FT /note="Interferon epsilon"
FT /id="PRO_0000317631"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 53..163
FT /evidence="ECO:0000250"
FT VARIANT 46
FT /note="Q -> H (in dbSNP:rs1125488)"
FT /id="VAR_049639"
SQ SEQUENCE 208 AA; 24414 MW; 65FB861407F14E5F CRC64;
MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF
LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL
EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF
SLTEKLSKQG RPLNDMKQEL TTEFRSPR
