IFNE_MOUSE
ID IFNE_MOUSE Reviewed; 192 AA.
AC Q80ZF2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Interferon epsilon;
DE Short=IFN-epsilon;
DE AltName: Full=Interferon epsilon-1;
DE AltName: Full=Interferon tau-1;
DE Flags: Precursor;
GN Name=Ifne; Synonyms=Ifne1, Ifnt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15233997; DOI=10.1016/j.ygeno.2004.03.003;
RA Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdebaeck M., Hertzog P.J.;
RT "Characterization of the type I interferon locus and identification of
RT novel genes.";
RL Genomics 84:331-345(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=23449591; DOI=10.1126/science.1233321;
RA Fung K.Y., Mangan N.E., Cumming H., Horvat J.C., Mayall J.R., Stifter S.A.,
RA De Weerd N., Roisman L.C., Rossjohn J., Robertson S.A., Schjenken J.E.,
RA Parker B., Gargett C.E., Nguyen H.P., Carr D.J., Hansbro P.M.,
RA Hertzog P.J.;
RT "Interferon-epsilon protects the female reproductive tract from viral and
RT bacterial infection.";
RL Science 339:1088-1092(2013).
CC -!- FUNCTION: Type I interferon required for maintaining basal levels of
CC IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7
CC and ISG15, in the female reproductive tract. Directly mediates
CC protection against viral, including HSV-2, and bacterial, including
CC Chlamydia muridarum, genital infections. {ECO:0000269|PubMed:23449591}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at very high levels in uterus and, at
CC much lower levels, in ovary and cervix. Very low levels, if any, in
CC other organs. In the endometrium, expressed in the luminal and
CC glandular epithelial cells (at protein level).
CC {ECO:0000269|PubMed:15233997, ECO:0000269|PubMed:23449591}.
CC -!- DEVELOPMENTAL STAGE: Expression varies approximately 30-fold during the
CC estrous cycle, with lowest levels during diestrus and highest at
CC estrus. During pregnancy, uterine expression is dramatically reduced at
CC 1.5 dpc and reaches its lowest levels at 4.5 dpc, coincident with the
CC time of embryo implantation. {ECO:0000269|PubMed:23449591}.
CC -!- INDUCTION: By estrogens. Contrary to other type I interferons, not
CC induced by known pattern-recognition receptor pathways.
CC {ECO:0000269|PubMed:23449591}.
CC -!- DISRUPTION PHENOTYPE: Mutant females are substantially more susceptible
CC to (and less able to clear) an ascending infection in the reproductive
CC tract than wild-type animals. {ECO:0000269|PubMed:23449591}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; AY190044; AAO38685.1; -; mRNA.
DR EMBL; AL805899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104376; AAI04377.1; -; mRNA.
DR EMBL; BC104377; AAI04378.1; -; mRNA.
DR CCDS; CCDS18348.1; -.
DR RefSeq; NP_796322.1; NM_177348.2.
DR AlphaFoldDB; Q80ZF2; -.
DR SMR; Q80ZF2; -.
DR STRING; 10090.ENSMUSP00000059199; -.
DR PhosphoSitePlus; Q80ZF2; -.
DR MaxQB; Q80ZF2; -.
DR PaxDb; Q80ZF2; -.
DR PRIDE; Q80ZF2; -.
DR ProteomicsDB; 267201; -.
DR Antibodypedia; 24882; 147 antibodies from 21 providers.
DR DNASU; 230405; -.
DR Ensembl; ENSMUST00000056014; ENSMUSP00000059199; ENSMUSG00000045364.
DR GeneID; 230405; -.
DR KEGG; mmu:230405; -.
DR UCSC; uc008tod.1; mouse.
DR CTD; 338376; -.
DR MGI; MGI:2667156; Ifne.
DR VEuPathDB; HostDB:ENSMUSG00000045364; -.
DR eggNOG; ENOG502S65R; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; Q80ZF2; -.
DR OMA; QQCLPHR; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q80ZF2; -.
DR TreeFam; TF336177; -.
DR BioGRID-ORCS; 230405; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q80ZF2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80ZF2; protein.
DR Bgee; ENSMUSG00000045364; Expressed in floor plate of diencephalon and 5 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IMP:UniProtKB.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..192
FT /note="Interferon epsilon"
FT /id="PRO_0000317632"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 192 AA; 22372 MW; F7A9A73B35DDE082 CRC64;
MVHRQLPETV LLLLVSSTIF SLEPKRIPFQ LWMNRESLQL LKPLPSSSVQ QCLAHRKNFL
LPQQPVSPHQ YQEGQVLAVV HEILQQIFTL LQTHGTMGIW EENHIEKVLA ALHRQLEYVE
SLGGLNAAQK SGGSSAQNLR LQIKAYFRRI HDYLENQRYS SCAWIIVQTE IHRCMFFVFR
FTTWLSRQDP DP
