ID   IFNE_PIG                Reviewed;         193 AA.
AC   A7UHZ5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Interferon epsilon;
DE            Short=IFN-epsilon;
DE   AltName: Full=Interferon epsilon-1;
DE   Flags: Precursor;
GN   Name=IFNE; Synonyms=IFNE1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tai Y.-L., Wang Y.-L., Zhang Z.-Q., Han L.-Q., Wang W.-J., Wang Y.-Y.,
RA   Zhong K., Guo Y.-J., Zhu H.-S., Yang G.-Y.;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Type I interferon required for maintaining basal levels of
CC       IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7
CC       and ISG15, in the female reproductive tract. Directly mediates
CC       protection against viral and bacterial genital infections (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; EU072421; ABU49642.1; -; mRNA.
DR   RefSeq; NP_001098780.1; NM_001105310.1.
DR   RefSeq; XP_005660117.1; XM_005660060.2.
DR   AlphaFoldDB; A7UHZ5; -.
DR   SMR; A7UHZ5; -.
DR   STRING; 9823.ENSSSCP00000005523; -.
DR   PaxDb; A7UHZ5; -.
DR   PRIDE; A7UHZ5; -.
DR   Ensembl; ENSSSCT00000005664; ENSSSCP00000005523; ENSSSCG00000005136.
DR   Ensembl; ENSSSCT00025052699; ENSSSCP00025022465; ENSSSCG00025038786.
DR   Ensembl; ENSSSCT00035057690; ENSSSCP00035023174; ENSSSCG00035043430.
DR   Ensembl; ENSSSCT00045006432; ENSSSCP00045004372; ENSSSCG00045003884.
DR   Ensembl; ENSSSCT00065026654; ENSSSCP00065010955; ENSSSCG00065020010.
DR   GeneID; 100125969; -.
DR   KEGG; ssc:100125969; -.
DR   CTD; 338376; -.
DR   VGNC; VGNC:89039; IFNE.
DR   eggNOG; ENOG502S65R; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_1_0_1; -.
DR   InParanoid; A7UHZ5; -.
DR   OMA; QQCLPHR; -.
DR   OrthoDB; 1358010at2759; -.
DR   TreeFam; TF336177; -.
DR   Proteomes; UP000008227; Chromosome 1.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000005136; Expressed in granulosa cell and 9 other tissues.
DR   ExpressionAtlas; A7UHZ5; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; ISS:UniProtKB.
DR   GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..193
FT                   /note="Interferon epsilon"
FT                   /id="PRO_0000317633"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..163
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  22851 MW;  60016CD37455C83E CRC64;
     MINKSFFEIM LVLLASSTGF SRELKLVLSQ QRRVNRESLK LLNKLQTSSI QQCLPHRKNF
     LLPQKSMNPH QYQKQQALAI LHEMLQQIFS LFRAVISLDG WEESHMEEFL VELHQQLEYL
     EALMRLQAEQ KSDTLCSENL TLQVKMYFQR IRDYLENQDY SSCAWTIVRV EINRCLFFVF
     QLTGKLSKQG MEP