IFNG1_ORYLA
ID IFNG1_ORYLA Reviewed; 200 AA.
AC H2N2P1;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Interferon gamma 1 {ECO:0000303|PubMed:29742458};
DE AltName: Full=Interferon gamma 2 {ECO:0000303|PubMed:25458697};
DE Flags: Precursor;
GN Name=ifng1 {ECO:0000303|PubMed:29742458};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000312|Proteomes:UP000001038};
RN [1] {ECO:0000312|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000312|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000305}
RP IDENTIFICATION OF ISOFORMS A AND B, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=25458697; DOI=10.1016/j.mce.2014.10.012;
RA Mohapatra S., Chakraborty T., Miyagawa S., Zhou L., Ohta K., Iguchi T.,
RA Nagahama Y.;
RT "Steroid responsive regulation of IFNgamma2 alternative splicing and its
RT possible role in germ cell proliferation in medaka.";
RL Mol. Cell. Endocrinol. 400:61-70(2015).
RN [3] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=29742458; DOI=10.1016/j.fsi.2018.05.008;
RA Zahradnik J., Kolarova L., Parizkova H., Kolenko P., Schneider B.;
RT "Interferons type II and their receptors R1 and R2 in fish species:
RT Evolution, structure, and function.";
RL Fish Shellfish Immunol. 79:140-152(2018).
CC -!- FUNCTION: Probable cytokine. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A {ECO:0000303|PubMed:25458697};
CC IsoId=H2N2P1-1; Sequence=Displayed;
CC Name=B {ECO:0000303|PubMed:25458697};
CC IsoId=H2N2P1-2; Sequence=VSP_059871, VSP_059872;
CC -!- TISSUE SPECIFICITY: Isoform A: Widely expressed. Isoform B:
CC Specifically expressed in ovary and testis, with strongest expression
CC in ovary. {ECO:0000269|PubMed:25458697}.
CC -!- INDUCTION: Isoform B is up-regulated in response to 17-beta-estradiol
CC (E2). {ECO:0000269|PubMed:25458697}.
CC -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC {ECO:0000305}.
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DR RefSeq; XP_004087027.2; XM_004086979.2. [H2N2P1-1]
DR AlphaFoldDB; H2N2P1; -.
DR SMR; H2N2P1; -.
DR Ensembl; ENSORLT00000045190; ENSORLP00000038656; ENSORLG00000027228. [H2N2P1-1]
DR GeneID; 101168445; -.
DR KEGG; ola:101168445; -.
DR GeneTree; ENSGT00390000007831; -.
DR HOGENOM; CLU_1331579_0_0_1; -.
DR InParanoid; H2N2P1; -.
DR OMA; LWELPWL; -.
DR OrthoDB; 1236990at2759; -.
DR TreeFam; TF344072; -.
DR Proteomes; UP000001038; Chromosome 23.
DR Proteomes; UP000265180; Unplaced.
DR Proteomes; UP000265200; Unplaced.
DR Bgee; ENSORLG00000027228; Expressed in pharyngeal gill and 2 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002069; Interferon_gamma.
DR PANTHER; PTHR11419; PTHR11419; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytokine; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..200
FT /note="Interferon gamma 1"
FT /id="PRO_5003565595"
FT REGION 91..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 156..158
FT /note="MDN -> VWR (in isoform B)"
FT /evidence="ECO:0000305|PubMed:25458697"
FT /id="VSP_059871"
FT VAR_SEQ 159..200
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305|PubMed:25458697"
FT /id="VSP_059872"
SQ SEQUENCE 200 AA; 23212 MW; 0EADE845EA78FD7F CRC64;
MMMMALMKVI LCLWLTVTGV SASYVPQEMN KTIQNLLQHY KIPLVERFNG NPVFPKDSMD
GNVEMKMIFM HGVLETYEDL IGHMLKQLPT ASPPLGSNQD KPASPGTSND DAAPVKADVR
SKLMYILEKI QFLKTHRYQE QEKLLHRLQN LKKIQMDNRT VQSKALWELP QLFEKASSLA
DNTMRRRRRR QARNRMRLKA
