ID   IFNGR_CARAU             Reviewed;         166 AA.
AC   C8AW45;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Interferon gamma-related {ECO:0000303|PubMed:20507977};
DE   AltName: Full=Interferon gamma 1 {ECO:0000303|PubMed:19577303};
DE   Flags: Precursor;
GN   Name=ifng1r {ECO:0000303|PubMed:20507977};
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000312|EMBL:ACV41807.1};
RN   [1] {ECO:0000312|EMBL:ACV41807.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=19577303; DOI=10.1016/j.molimm.2009.06.004;
RA   Grayfer L., Belosevic M.;
RT   "Molecular characterization of novel interferon gamma receptor 1 isoforms
RT   in zebrafish (Danio rerio) and goldfish (Carassius auratus L.).";
RL   Mol. Immunol. 46:3050-3059(2009).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=20507977; DOI=10.1074/jbc.m109.096925;
RA   Grayfer L., Garcia E.G., Belosevic M.;
RT   "Comparison of macrophage antimicrobial responses induced by type II
RT   interferons of the goldfish (Carassius auratus L.).";
RL   J. Biol. Chem. 285:23537-23547(2010).
CC   -!- FUNCTION: Cytokine which binds to interferon gamma receptor 1 (ifngr1)
CC       (PubMed:19577303, PubMed:20507977). Has activating effects on primary
CC       macrophages (PubMed:20507977). Induces nitric oxide production and
CC       phagocytic responses in macrophages (PubMed:20507977). Primes monocytes
CC       for production of reactive oxygen intermediates (ROI), although the
CC       effect is short-lived (PubMed:20507977). Also has inhibitory effects on
CC       monocyte priming by ifng1 (interferon gamma 1) and tnfb (TNF-alpha 2)
CC       (PubMed:20507977). Stimulates phosphorylation of the JAK/STAT signal
CC       transducer stat1, but fails to induce stat1 nuclear localization
CC       (PubMed:20507977). Promotes increased expression of a number of genes
CC       important for macrophage activity, including the interferon regulatory
CC       factors irf2 and irf9 (PubMed:20507977). {ECO:0000269|PubMed:19577303,
CC       ECO:0000269|PubMed:20507977}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:19577303}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19577303,
CC       ECO:0000305|PubMed:20507977}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in spleen. Also detected at
CC       lower levels in gill, kidney, heart, brain and intestine. In immune
CC       cell populations, expressed at highest levels in peripheral blood
CC       leukocytes and at lower levels in splenocytes, granulocytes, monocytes
CC       and macrophages. {ECO:0000269|PubMed:20507977}.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; GQ149696; ACV41807.1; -; mRNA.
DR   AlphaFoldDB; C8AW45; -.
DR   SMR; C8AW45; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; PTHR11419; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..166
FT                   /note="Interferon gamma-related"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5002987380"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   166 AA;  19196 MW;  C52D7B0C121A1622 CRC64;
     MYCRLNMVYL ICALLLIVSL QGTVGARLPQ SQKDKEQMLK NVREKIESLQ KHYHTTGTEW
     FGKSVLSSHL HQLNSKASCT CQSLLLDSML NITETIFQDM RGKAENEETK TSLRDVMTEV
     KMLRHKYSEE QKVWRELQDI HSVEVNNGKI QKGALNSFLI LYDLAY