ID   IFNG_ANAPL              Reviewed;         164 AA.
AC   Q9YGB9;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Interferon gamma;
DE            Short=IFN-gamma;
DE   Flags: Precursor;
GN   Name=IFNG;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10074168; DOI=10.1128/jvi.73.4.3162-3168.1999;
RA   Schultz U., Chisari F.V.;
RT   "Recombinant duck interferon gamma inhibits duck hepatitis B virus
RT   replication in primary hepatocytes.";
RL   J. Virol. 73:3162-3168(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang A., Jilbert A.R., Kotlarski I., Miller D.S., Scougall C.A.,
RA   Burrell C.J.;
RT   "Cloning and expression of duck interferon-gamma.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by lymphocytes activated by specific antigens or
CC       mitogens. IFN-gamma, in addition to having antiviral activity, has
CC       important immunoregulatory functions. It is a potent activator of
CC       macrophages, it has antiproliferative effects on transformed cells and
CC       it can potentiate the antiviral and antitumor effects of the type I
CC       interferons.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; AF087134; AAD05221.1; -; mRNA.
DR   EMBL; AF100929; AAC72980.1; -; mRNA.
DR   EMBL; AJ012254; CAA09967.1; -; mRNA.
DR   RefSeq; NP_001297346.1; NM_001310417.1.
DR   AlphaFoldDB; Q9YGB9; -.
DR   SMR; Q9YGB9; -.
DR   Ensembl; ENSAPLT00020016264; ENSAPLP00020015099; ENSAPLG00020010948.
DR   GeneID; 101790439; -.
DR   KEGG; apla:101790439; -.
DR   CTD; 3458; -.
DR   HOGENOM; CLU_135106_0_0_1; -.
DR   OMA; GGPIFTE; -.
DR   OrthoDB; 1382686at2759; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0002281; P:macrophage activation involved in immune response; TAS:AgBase.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; PTHR11419; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Glycoprotein; Growth regulation; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..164
FT                   /note="Interferon gamma"
FT                   /id="PRO_0000016462"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  18847 MW;  87F2F184F0A8D91E CRC64;
     MTCQTYCLFV LSVIMIYFGC SGSALFLGQL QNDIDKLKAD FNASNSDVAD GNPVFIEKVK
     NWTERNEKRI ILSQIVTLYL EMLKKTDMSK PHIKNLSEQL NTLRNTLSND YKKFRDLVEL
     SNLQLTGLKI QRKAVSELFS VLQKLVETST SKRKRSQSPK RCRC