ID   APH1B_PONAB             Reviewed;         257 AA.
AC   Q5RDM3;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Gamma-secretase subunit APH-1B;
DE            Short=APH-1b;
DE   AltName: Full=Aph-1beta;
GN   Name=APH1B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable subunit of the gamma-secretase complex, an
CC       endoprotease complex that catalyzes the intramembrane cleavage of
CC       integral proteins such as Notch receptors and APP (amyloid-beta
CC       precursor protein). It probably represents a stabilizing cofactor for
CC       the presenilin homodimer that promotes the formation of a stable
CC       complex. Probably present in a minority of gamma-secretase complexes
CC       compared to APH1A (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the gamma-secretase complex, a complex
CC       composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN),
CC       APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for
CC       secretase activity, although other components may exist. Interacts with
CC       PSEN1 and PSEN2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the APH-1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR857881; CAH90134.1; -; mRNA.
DR   RefSeq; NP_001125030.1; NM_001131558.1.
DR   AlphaFoldDB; Q5RDM3; -.
DR   SMR; Q5RDM3; -.
DR   STRING; 9601.ENSPPYP00000007417; -.
DR   Ensembl; ENSPPYT00000007721; ENSPPYP00000007417; ENSPPYG00000006539.
DR   GeneID; 100171910; -.
DR   KEGG; pon:100171910; -.
DR   CTD; 83464; -.
DR   eggNOG; KOG3972; Eukaryota.
DR   GeneTree; ENSGT00390000002049; -.
DR   HOGENOM; CLU_086389_0_0_1; -.
DR   InParanoid; Q5RDM3; -.
DR   OMA; EKKKWYV; -.
DR   OrthoDB; 1085102at2759; -.
DR   TreeFam; TF314362; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0070765; C:gamma-secretase complex; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   GO; GO:0061133; F:endopeptidase activator activity; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
DR   GO; GO:0007220; P:Notch receptor processing; IEA:Ensembl.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR   InterPro; IPR009294; Aph-1.
DR   PANTHER; PTHR12889; PTHR12889; 1.
DR   Pfam; PF06105; Aph-1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Notch signaling pathway; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..257
FT                   /note="Gamma-secretase subunit APH-1B"
FT                   /id="PRO_0000221054"
FT   TRANSMEM        5..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   257 AA;  28519 MW;  911DEA19B41B494B CRC64;
     MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGAF FWLVSLLISS LVWFMARVII
     DNKDGPTQKY LLIFGTFVSV YIQEMFRFAY YRLLKKASEG LKSINPGETA PSMRLLAYVS
     GLGFGIMSGV FSFVNTLSDS LGPGTVGIHG DSPQFFLYSA FMTLVIILLH VFWGIVFFDG
     CEKKKWGILL IVLLTHLLVS AQTFISSYYG INLASAFIIL VLMGTWAFLA AGGSCRSLKL
     CLLCQDKDFL LYNQRSR