IFNG_CHICK
ID IFNG_CHICK Reviewed; 164 AA.
AC P49708; D3GGX1; Q53YS2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Interferon gamma;
DE Short=IFN-gamma;
DE Flags: Precursor;
GN Name=IFNG;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8590305; DOI=10.1089/jir.1995.15.939;
RA Digby M.R., Lowenthal J.W.;
RT "Cloning and expression of the chicken interferon-gamma gene.";
RL J. Interferon Cytokine Res. 15:939-945(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8898958; DOI=10.1002/eji.1830261026;
RA Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.;
RT "Biological properties of recombinant chicken interferon-gamma.";
RL Eur. J. Immunol. 26:2440-2447(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=N LINE;
RX PubMed=9511740; DOI=10.1016/s0378-1119(97)00600-8;
RA Kaiser P., Wain H.M., Rothwell L.;
RT "Structure of the chicken interferon-gamma gene, and comparison to
RT mammalian homologues.";
RL Gene 207:25-32(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=White leghorn; TISSUE=Spleen;
RA Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.;
RT "Molecular genetic analysis of chicken interferon gamma gene.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RA Lv Y.Z., Cao Y.C., Bi Y.Z.;
RT "Chicken interferon-gamma.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RA Bao M., Zhong D., Xu F., Yu W.;
RT "Cloning and expression of the chicken interferon-gamma gene.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peripheral blood lymphocyte;
RA Zhang X., Zhang C., Li Y., Cheng X., Wu T.;
RT "Cloning and sequence analysis of interferon gamma of China Lushi
RT chicken.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Produced by lymphocytes activated by specific antigens or
CC mitogens. IFN-gamma, in addition to having antiviral activity, has
CC important immunoregulatory functions. It is a potent activator of
CC macrophages, it has antiproliferative effects on transformed cells and
CC it can potentiate the antiviral and antitumor effects of the type I
CC interferons (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC {ECO:0000305}.
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DR EMBL; U27465; AAC59723.1; -; mRNA.
DR EMBL; X99774; CAA68118.1; -; mRNA.
DR EMBL; Y07922; CAA69227.1; -; Genomic_DNA.
DR EMBL; U96875; AAG27918.1; -; Genomic_DNA.
DR EMBL; U96872; AAG27918.1; JOINED; Genomic_DNA.
DR EMBL; U96873; AAG27918.1; JOINED; Genomic_DNA.
DR EMBL; U96874; AAG27918.1; JOINED; Genomic_DNA.
DR EMBL; AF424744; AAL17845.1; -; mRNA.
DR EMBL; AY501004; AAR98863.1; -; mRNA.
DR EMBL; FJ788637; ACY72343.1; -; mRNA.
DR PIR; JC6536; JC6536.
DR RefSeq; NP_990480.1; NM_205149.1.
DR AlphaFoldDB; P49708; -.
DR SMR; P49708; -.
DR STRING; 9031.ENSGALP00000016086; -.
DR PaxDb; P49708; -.
DR Ensembl; ENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
DR GeneID; 396054; -.
DR KEGG; gga:396054; -.
DR CTD; 3458; -.
DR VEuPathDB; HostDB:geneid_396054; -.
DR eggNOG; ENOG502SBGW; Eukaryota.
DR GeneTree; ENSGT00390000007831; -.
DR HOGENOM; CLU_135106_0_0_1; -.
DR InParanoid; P49708; -.
DR OMA; GGPIFTE; -.
DR OrthoDB; 1382686at2759; -.
DR PhylomeDB; P49708; -.
DR TreeFam; TF336308; -.
DR Reactome; R-GGA-877300; Interferon gamma signaling.
DR Reactome; R-GGA-877312; Regulation of IFNG signaling.
DR PRO; PR:P49708; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000009903; Expressed in granulocyte and 6 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:AgBase.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0042116; P:macrophage activation; IDA:AgBase.
DR GO; GO:0045918; P:negative regulation of cytolysis; IDA:AgBase.
DR GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:AgBase.
DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; TAS:AgBase.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0070673; P:response to interleukin-18; IDA:AgBase.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002069; Interferon_gamma.
DR PANTHER; PTHR11419; PTHR11419; 1.
DR Pfam; PF00714; IFN-gamma; 1.
DR PIRSF; PIRSF001936; IFN-gamma; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..164
FT /note="Interferon gamma"
FT /id="PRO_0000016463"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 164 AA; 18953 MW; 18D9B0BCA415B600 CRC64;
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD GGPIIVEKLK
NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL YTLKNNLPDG VKKVKDIMDL
AKLPMNDLRI QRKAANELFS ILQKLVDPPS FKRKRSQSQR RCNC
