ID   IFNG_MARMO              Reviewed;         166 AA.
AC   O35735; O88641; Q6X659;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Interferon gamma;
DE            Short=IFN-gamma;
DE   Flags: Precursor;
GN   Name=IFNG;
OS   Marmota monax (Woodchuck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Marmota.
OX   NCBI_TaxID=9995;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peripheral blood;
RX   PubMed=9472070; DOI=10.1007/s002510050366;
RA   Lohrengel B., Lu M., Roggendorf M.;
RT   "Molecular cloning of the woodchuck cytokines: TNF-alpha, IFN-gamma, and
RT   IL-6.";
RL   Immunogenetics 47:332-335(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10627561; DOI=10.1128/jvi.74.3.1495-1505.2000;
RA   Guo J.T., Zhou H., Liu C., Aldrich C., Saputelli J., Whitaker T.,
RA   Barrasa M.I., Mason W.S., Seeger C.;
RT   "Apoptosis and regeneration of hepatocytes during recovery from transient
RT   hepadnavirus infections.";
RL   J. Virol. 74:1495-1505(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10775584; DOI=10.1128/jvi.74.10.4483-4494.2000;
RA   Michalak T.I., Hodgson P.D., Churchill N.D.;
RT   "Posttranscriptional inhibition of class I major histocompatibility complex
RT   presentation on hepatocytes and lymphoid cells in chronic woodchuck
RT   hepatitis virus infection.";
RL   J. Virol. 74:4483-4494(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang Y., Jacob J.R., Menne S., Bellezza C.A., Tennant B.C., Gerin J.L.,
RA   Cote P.J.;
RT   "Role of interferon-gamma-related response in woodchuck hepatitis virus
RT   infection and viral clearance from hepatocytes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by lymphocytes activated by specific antigens or
CC       mitogens. IFN-gamma, in addition to having antiviral activity, has
CC       important immunoregulatory functions. It is a potent activator of
CC       macrophages, it has antiproliferative effects on transformed cells and
CC       it can potentiate the antiviral and antitumor effects of the type I
CC       interferons.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; Y14138; CAA74570.1; -; mRNA.
DR   EMBL; AF081502; AAC31963.1; -; mRNA.
DR   EMBL; AF232728; AAF68960.1; -; mRNA.
DR   EMBL; AY253722; AAP80574.1; -; mRNA.
DR   AlphaFoldDB; O35735; -.
DR   SMR; O35735; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; PTHR11419; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..166
FT                   /note="Interferon gamma"
FT                   /id="PRO_0000016450"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01579"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        7
FT                   /note="I -> F (in Ref. 2; AAC31963 and 3; AAF68960)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        12
FT                   /note="L -> F (in Ref. 4; AAP80574)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="I -> V (in Ref. 1; CAA74570)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="I -> N (in Ref. 1; CAA74570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   166 AA;  19161 MW;  49207267AC930D03 CRC64;
     MKYTSYILAF QLCIILGSSS CYSQDTVNKE IEDLKGYFNA SNSNVSDGGS LFLDILDKWK
     EESDKKVIQS QIVSFYFKLF EHLKDNKIIQ RSMDTIKGDL FAKFFNSSTN KLQDFLKVSQ
     VQVNDLKIQR KAVSELKKVM NDLLPHSTLR KRKRSQSSIR GRRASK