ID   IFNG_MUSPF              Reviewed;         166 AA.
AC   A4PIZ9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Interferon gamma;
DE            Short=IFN-gamma;
DE   Flags: Precursor;
GN   Name=IFNG;
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Mustela.
OX   NCBI_TaxID=9669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Nakata M., Itou T., Sakai T.;
RT   "Mustela putorius furo interferon-gamma.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Type II interferon produced by immune cells such as T-cells
CC       and NK cells that plays crucial roles in antimicrobial, antiviral, and
CC       antitumor responses by activating effector immune cells and enhancing
CC       antigen presentation. Primarily signals through the JAK-STAT pathway
CC       after interaction with its receptor IFNGR1 to affect gene regulation.
CC       Upon IFNG binding, IFNGR1 intracellular domain opens out to allow
CC       association of downstream signaling components JAK2, JAK1 and STAT1,
CC       leading to STAT1 activation, nuclear translocation and transcription of
CC       IFNG-regulated genes. Many of the induced genes are transcription
CC       factors such as IRF1 that are able to further drive regulation of a
CC       next wave of transcription. Plays a role in class I antigen
CC       presentation pathway by inducing a replacement of catalytic proteasome
CC       subunits with immunoproteasome subunits. In turn, increases the
CC       quantity, quality, and repertoire of peptides for class I MHC loading.
CC       Increases the efficiency of peptide generation also by inducing the
CC       expression of activator PA28 that associates with the proteasome and
CC       alters its proteolytic cleavage preference. Up-regulates as well MHC II
CC       complexes on the cell surface by promoting expression of several key
CC       molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By
CC       similarity). Participates in the regulation of hematopoietic stem cells
CC       during development and under homeostatic conditions by affecting their
CC       development, quiescence, and differentiation (By similarity).
CC       {ECO:0000250|UniProtKB:P01579, ECO:0000250|UniProtKB:P01580}.
CC   -!- SUBUNIT: Homodimer. Interacts with IFNGR1 (via extracellular domain);
CC       this interaction promotes IFNGR1 dimerization.
CC       {ECO:0000250|UniProtKB:P01579}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; AB300566; BAF56574.1; -; mRNA.
DR   AlphaFoldDB; A4PIZ9; -.
DR   SMR; A4PIZ9; -.
DR   STRING; 9669.ENSMPUP00000017401; -.
DR   eggNOG; ENOG502SBGW; Eukaryota.
DR   InParanoid; A4PIZ9; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; PTHR11419; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..166
FT                   /note="Interferon gamma"
FT                   /id="PRO_5000235046"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P01579"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  19613 MW;  74A8101AB06CB6AF CRC64;
     MNYTTICLAF QLCVIFCSSG YYCQAMFFKE IEDLKEYFNA SNPDVADGGP LFLDILKNWR
     EESDKKIIQS QIVSFYLKLF ENFKDNQIIQ RSMDTIKEDM LVRFFNNSSS KLEDFLKLIR
     IPVNDLQVQR KAINELIKVM NDLSPRSNLR KRKRSHSLFR GRRASK