ID   IFNG_NUMME              Reviewed;         164 AA.
AC   O73915;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Interferon gamma;
DE            Short=IFN-gamma;
DE   Flags: Precursor;
GN   Name=IFNG;
OS   Numida meleagris (Helmeted guineafowl) (Phasianus meleagris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Numididae;
OC   Numida.
OX   NCBI_TaxID=8996;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kaiser P., Sonnemans D., Smith L.M.;
RT   "Avian interferon-gamma: cloning, sequencing and comparison of interferon-
RT   gamma genes from several different avian species.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produced by lymphocytes activated by specific antigens or
CC       mitogens. IFN-gamma, in addition to having antiviral activity, has
CC       important immunoregulatory functions. It is a potent activator of
CC       macrophages, it has antiproliferative effects on transformed cells and
CC       it can potentiate the antiviral and antitumor effects of the type I
CC       interferons (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
CC       {ECO:0000305}.
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DR   EMBL; AJ001263; CAA04637.1; -; Genomic_DNA.
DR   AlphaFoldDB; O73915; -.
DR   SMR; O73915; -.
DR   STRING; 8996.ENSNMEP00000013494; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002069; Interferon_gamma.
DR   PANTHER; PTHR11419; PTHR11419; 1.
DR   Pfam; PF00714; IFN-gamma; 1.
DR   PIRSF; PIRSF001936; IFN-gamma; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Glycoprotein; Growth regulation; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..164
FT                   /note="Interferon gamma"
FT                   /id="PRO_0000016466"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  18831 MW;  7DDCCC76D5CAA8BB CRC64;
     MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD GGPIFIEKLK
     NWTGSNEKKI ILSQIVSMYL EMFENTDQSK PHIKHISEEL CTLRDSLSDG VKKVKDLMDL
     AKLQMTDLRI QRKAANELFI VLQKLVDPPS LKRKRNQPQR RCNC