IFNK_MOUSE
ID IFNK_MOUSE Reviewed; 199 AA.
AC Q7TSL0;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Interferon kappa;
DE Short=IFN-kappa;
DE Flags: Precursor;
GN Name=Ifnk;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=129/Sv;
RX PubMed=12759458; DOI=10.4049/jimmunol.170.11.5748;
RA Vassileva G., Chen S.-C., Zeng M., Abbondanzo S., Jensen K., Gorman D.,
RA Baroudy B.M., Jiang Y., Murgolo N., Lira S.A.;
RT "Expression of a novel murine type I IFN in the pancreatic islets induces
RT diabetes in mice.";
RL J. Immunol. 170:5748-5755(2003).
CC -!- FUNCTION: May play a role in the regulation of immune cell function.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in peritoneal macrophages.
CC {ECO:0000269|PubMed:12759458}.
CC -!- INDUCTION: Upon exposure to double-stranded RNA and interferon-gamma.
CC {ECO:0000269|PubMed:12759458}.
CC -!- MISCELLANEOUS: Transgenic mice overexpressing IFNK in the pancreas,
CC develop insulin-dependent (type I) diabete.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; AF547990; AAP43908.1; -; Genomic_DNA.
DR CCDS; CCDS18037.1; -.
DR RefSeq; NP_954608.1; NM_199157.2.
DR AlphaFoldDB; Q7TSL0; -.
DR SMR; Q7TSL0; -.
DR STRING; 10090.ENSMUSP00000054273; -.
DR PhosphoSitePlus; Q7TSL0; -.
DR PaxDb; Q7TSL0; -.
DR PRIDE; Q7TSL0; -.
DR ProteomicsDB; 269380; -.
DR Antibodypedia; 25005; 91 antibodies from 18 providers.
DR DNASU; 387510; -.
DR Ensembl; ENSMUST00000058595; ENSMUSP00000054273; ENSMUSG00000042993.
DR GeneID; 387510; -.
DR KEGG; mmu:387510; -.
DR UCSC; uc008sgu.1; mouse.
DR CTD; 56832; -.
DR MGI; MGI:2683287; Ifnk.
DR VEuPathDB; HostDB:ENSMUSG00000042993; -.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR InParanoid; Q7TSL0; -.
DR OMA; FCAWKIV; -.
DR OrthoDB; 1358010at2759; -.
DR PhylomeDB; Q7TSL0; -.
DR TreeFam; TF336177; -.
DR BioGRID-ORCS; 387510; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q7TSL0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q7TSL0; protein.
DR Bgee; ENSMUSG00000042993; Expressed in ectoplacental cone and 17 other tissues.
DR ExpressionAtlas; Q7TSL0; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; ISO:MGI.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..199
FT /note="Interferon kappa"
FT /id="PRO_0000016411"
FT DISULFID 24..119
FT /evidence="ECO:0000250"
FT DISULFID 49..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 199 AA; 23581 MW; 400851D060A376A9 CRC64;
MTPKFLWLVA LVALYIPPIQ SLNCVYLDDS ILENVKLLGS TMTGFPLRCL KDITDFKFPK
EILPYIQHMK REINAVSYRI SSLALTIFNL KGSIPPVTEE HWERIRSGLF KQVRQAQECF
MDEEKENREH PHSEDFLTVY LELGKYFFRI KKFLINKKYS FCAWKIVTVE IRRCFIIFSK
SRKLLKMISE SPTFKQELK
