IFNL1_HUMAN
ID IFNL1_HUMAN Reviewed; 200 AA.
AC Q8IU54; A0AV25; Q17R34;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Interferon lambda-1;
DE Short=IFN-lambda-1;
DE AltName: Full=Cytokine Zcyto21;
DE AltName: Full=Interleukin-29;
DE Short=IL-29;
DE Flags: Precursor;
GN Name=IFNL1; Synonyms=IL29, ZCYTO21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12469119; DOI=10.1038/ni873;
RA Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S.,
RA Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J.,
RA Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B.,
RA Cooper E., Taft D., Gilbert T., Grant F.J., Tackett M., Krivan W.,
RA McKnight G., Clegg C., Foster D., Klucher K.M.;
RT "IL-28, IL-29 and their class II cytokine receptor IL-28R.";
RL Nat. Immunol. 4:63-68(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12483210; DOI=10.1038/ni875;
RA Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M.,
RA Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.;
RT "IFN-lambdas mediate antiviral protection through a distinct class II
RT cytokine receptor complex.";
RL Nat. Immunol. 4:69-77(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li M., He S.;
RT "Construction of mammalian cell expression vector of human interleukin
RT (IL)-28A, IL-28B and IL-29 gene from activated peripheral blood mononuclear
RT cell and analysis of its sequence.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-188.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP REVIEW.
RX PubMed=20712453; DOI=10.1089/jir.2010.0078;
RA Donnelly R.P., Kotenko S.V.;
RT "Interferon-lambda: a new addition to an old family.";
RL J. Interferon Cytokine Res. 30:555-564(2010).
RN [7]
RP REVIEW.
RX PubMed=24751921; DOI=10.1159/000360084;
RA Hermant P., Michiels T.;
RT "Interferon-lambda in the context of viral infections: production, response
RT and therapeutic implications.";
RL J. Innate Immun. 6:563-574(2014).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-200 IN COMPLEX WITH IFNLR1, AND
RP DISULFIDE BOND.
RX PubMed=20934432; DOI=10.1016/j.jmb.2010.09.068;
RA Miknis Z.J., Magracheva E., Li W., Zdanov A., Kotenko S.V., Wlodawer A.;
RT "Crystal structure of human interferon-lambda1 in complex with its high-
RT affinity receptor interferon-lambdaR1.";
RL J. Mol. Biol. 404:650-664(2010).
CC -!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
CC activities. Plays a critical role in the antiviral host defense,
CC predominantly in the epithelial tissues. Acts as a ligand for the
CC heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1,
CC and receptor engagement leads to the activation of the JAK/STAT
CC signaling pathway resulting in the expression of IFN-stimulated genes
CC (ISG), which mediate the antiviral state. Has a restricted receptor
CC distribution and therefore restricted targets: is primarily active in
CC epithelial cells and this cell type-selective action is because of the
CC epithelial cell-specific expression of its receptor IFNLR1. Exerts an
CC immunomodulatory effect by up-regulating MHC class I antigen
CC expression.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- INDUCTION: By viral infections or double-stranded RNA.
CC -!- SIMILARITY: Belongs to the lambda interferon family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-29 entry;
CC URL="https://en.wikipedia.org/wiki/Interleukin_29";
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DR EMBL; AY129150; AAN28265.1; -; mRNA.
DR EMBL; AY184372; AAN86125.1; -; mRNA.
DR EMBL; AY336716; AAR24511.1; -; mRNA.
DR EMBL; AC011445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074985; AAH74985.1; -; mRNA.
DR EMBL; BC126183; AAI26184.1; -; mRNA.
DR EMBL; BC117482; AAI17483.1; -; mRNA.
DR CCDS; CCDS12531.1; -.
DR RefSeq; NP_742152.1; NM_172140.1.
DR PDB; 3OG4; X-ray; 2.16 A; A=23-200.
DR PDB; 3OG6; X-ray; 2.10 A; A=20-200.
DR PDBsum; 3OG4; -.
DR PDBsum; 3OG6; -.
DR AlphaFoldDB; Q8IU54; -.
DR SMR; Q8IU54; -.
DR BioGRID; 129396; 10.
DR ComplexPortal; CPX-6011; Interferon lambda receptor-ligand complex, IFNL1 variant.
DR IntAct; Q8IU54; 3.
DR STRING; 9606.ENSP00000329991; -.
DR GlyGen; Q8IU54; 1 site.
DR iPTMnet; Q8IU54; -.
DR PhosphoSitePlus; Q8IU54; -.
DR BioMuta; IFNL1; -.
DR MassIVE; Q8IU54; -.
DR PaxDb; Q8IU54; -.
DR PeptideAtlas; Q8IU54; -.
DR PRIDE; Q8IU54; -.
DR ProteomicsDB; 70504; -.
DR Antibodypedia; 30288; 290 antibodies from 28 providers.
DR DNASU; 282618; -.
DR Ensembl; ENST00000333625.3; ENSP00000329991.1; ENSG00000182393.3.
DR GeneID; 282618; -.
DR KEGG; hsa:282618; -.
DR MANE-Select; ENST00000333625.3; ENSP00000329991.1; NM_172140.2; NP_742152.1.
DR UCSC; uc002okv.4; human.
DR CTD; 282618; -.
DR DisGeNET; 282618; -.
DR GeneCards; IFNL1; -.
DR HGNC; HGNC:18363; IFNL1.
DR HPA; ENSG00000182393; Not detected.
DR MIM; 607403; gene.
DR neXtProt; NX_Q8IU54; -.
DR OpenTargets; ENSG00000182393; -.
DR PharmGKB; PA134899000; -.
DR VEuPathDB; HostDB:ENSG00000182393; -.
DR eggNOG; ENOG502SSDC; Eukaryota.
DR GeneTree; ENSGT00390000014310; -.
DR HOGENOM; CLU_120266_0_0_1; -.
DR InParanoid; Q8IU54; -.
DR OMA; HWLQKLE; -.
DR OrthoDB; 1429532at2759; -.
DR PhylomeDB; Q8IU54; -.
DR TreeFam; TF336172; -.
DR PathwayCommons; Q8IU54; -.
DR Reactome; R-HSA-449836; Other interleukin signaling.
DR Reactome; R-HSA-8854691; Interleukin-20 family signaling.
DR SignaLink; Q8IU54; -.
DR SIGNOR; Q8IU54; -.
DR BioGRID-ORCS; 282618; 15 hits in 1063 CRISPR screens.
DR GeneWiki; Interleukin_29; -.
DR GenomeRNAi; 282618; -.
DR Pharos; Q8IU54; Tbio.
DR PRO; PR:Q8IU54; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IU54; protein.
DR Bgee; ENSG00000182393; Expressed in granulocyte and 15 other tissues.
DR Genevisible; Q8IU54; HS.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0032002; C:interleukin-28 receptor complex; IDA:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0032003; F:interleukin-28 receptor binding; IPI:UniProtKB.
DR GO; GO:0005102; F:signaling receptor binding; IDA:UniProtKB.
DR GO; GO:0098586; P:cellular response to virus; IC:ComplexPortal.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0032696; P:negative regulation of interleukin-13 production; IDA:UniProtKB.
DR GO; GO:0032714; P:negative regulation of interleukin-5 production; IDA:UniProtKB.
DR GO; GO:0043381; P:negative regulation of memory T cell differentiation; IDA:UniProtKB.
DR GO; GO:0045581; P:negative regulation of T cell differentiation; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0002829; P:negative regulation of type 2 immune response; IDA:UniProtKB.
DR GO; GO:0050778; P:positive regulation of immune response; TAS:UniProtKB.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:UniProtKB.
DR GO; GO:0045345; P:positive regulation of MHC class I biosynthetic process; IDA:UniProtKB.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:UniProtKB.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR GO; GO:0038196; P:type III interferon signaling pathway; IC:ComplexPortal.
DR Gene3D; 1.20.1250.60; -; 1.
DR InterPro; IPR038326; IFN-lambda_sf.
DR InterPro; IPR029177; INF_lambda.
DR PANTHER; PTHR31943; PTHR31943; 1.
DR Pfam; PF15177; IL28A; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antiviral defense; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..200
FT /note="Interferon lambda-1"
FT /id="PRO_0000015511"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 68..164
FT /evidence="ECO:0000269|PubMed:20934432"
FT VARIANT 188
FT /note="N -> D (in dbSNP:rs30461)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024506"
FT HELIX 44..61
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 87..105
FT /evidence="ECO:0007829|PDB:3OG6"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 111..129
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 145..159
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 162..178
FT /evidence="ECO:0007829|PDB:3OG6"
FT HELIX 180..186
FT /evidence="ECO:0007829|PDB:3OG6"
SQ SEQUENCE 200 AA; 21898 MW; D4433B9462DCB4A1 CRC64;
MAAAWTVVLV TLVLGLAVAG PVPTSKPTTT GKGCHIGRFK SLSPQELASF KKARDALEES
LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK VLEAAAGPAL EDVLDQPLHT
LHHILSQLQA CIQPQPTAGP RPRGRLHHWL HRLQEAPKKE SAGCLEASVT FNLFRLLTRD
LKYVADGNLC LRTSTHPEST
