IFNL2_MOUSE
ID IFNL2_MOUSE Reviewed; 193 AA.
AC Q4VK74; E9Q2S2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Interferon lambda-2 {ECO:0000303|PubMed:15914836};
DE Short=IFN-lambda-2 {ECO:0000303|PubMed:15914836};
DE AltName: Full=Interleukin-28A {ECO:0000312|MGI:MGI:3647279};
DE Short=IL-28A {ECO:0000250|UniProtKB:Q8IZJ0};
DE Flags: Precursor;
GN Name=Ifnl2; Synonyms=Il28a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAX58714.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=129/Sv {ECO:0000312|EMBL:AAX58714.1};
RX PubMed=15914836; DOI=10.1099/vir.0.80904-0;
RA Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.;
RT "Murine interferon lambdas (type III interferons) exhibit potent antiviral
RT activity in vivo in a poxvirus infection model.";
RL J. Gen. Virol. 86:1589-1596(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=16618774; DOI=10.1158/0008-5472.can-05-3653;
RA Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B.,
RA Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E.,
RA Kotenko S.V.;
RT "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-
RT lambdas exhibit antitumor activity against B16 melanoma.";
RL Cancer Res. 66:4468-4477(2006).
RN [4]
RP FUNCTION.
RX PubMed=18250457; DOI=10.4049/jimmunol.180.4.2474;
RA Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B.,
RA Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K.,
RA Paludan S.R.;
RT "An important role for type III interferon (IFN-lambda/IL-28) in TLR-
RT induced antiviral activity.";
RL J. Immunol. 180:2474-2485(2008).
RN [5]
RP REVIEW.
RX PubMed=20712453; DOI=10.1089/jir.2010.0078;
RA Donnelly R.P., Kotenko S.V.;
RT "Interferon-lambda: a new addition to an old family.";
RL J. Interferon Cytokine Res. 30:555-564(2010).
RN [6]
RP FUNCTION.
RX PubMed=21518880; DOI=10.1073/pnas.1100552108;
RA Pott J., Mahlakoiv T., Mordstein M., Duerr C.U., Michiels T.,
RA Stockinger S., Staeheli P., Hornef M.W.;
RT "IFN-lambda determines the intestinal epithelial antiviral host defense.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:7944-7949(2011).
RN [7]
RP REVIEW.
RX PubMed=24751921; DOI=10.1159/000360084;
RA Hermant P., Michiels T.;
RT "Interferon-lambda in the context of viral infections: production, response
RT and therapeutic implications.";
RL J. Innate Immun. 6:563-574(2014).
CC -!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
CC activities. Plays a critical role in the antiviral host defense,
CC predominantly in the epithelial tissues. Acts as a ligand for the
CC heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1,
CC and receptor engagement leads to the activation of the JAK/STAT
CC signaling pathway resulting in the expression of IFN-stimulated genes
CC (ISG), which mediate the antiviral state. Has a restricted receptor
CC distribution and therefore restricted targets: is primarily active in
CC epithelial cells and this cell type-selective action is because of the
CC epithelial cell-specific expression of its receptor IFNLR1. Seems not
CC to be essential for early virus-activated host defense in vaginal
CC infection, but plays an important role in Toll-like receptor (TLR)-
CC induced antiviral defense. Plays a significant role in the antiviral
CC immune defense in the intestinal epithelium. Exerts an immunomodulatory
CC effect by up-regulating MHC class I antigen expression.
CC {ECO:0000269|PubMed:15914836, ECO:0000269|PubMed:16618774,
CC ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
CC -!- SIMILARITY: Belongs to the lambda interferon family. {ECO:0000305}.
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DR EMBL; AY869695; AAX58714.1; -; mRNA.
DR EMBL; AC149606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS39861.1; -.
DR RefSeq; NP_001019844.2; NM_001024673.2.
DR AlphaFoldDB; Q4VK74; -.
DR SMR; Q4VK74; -.
DR STRING; 10090.ENSMUSP00000080384; -.
DR GlyGen; Q4VK74; 1 site.
DR iPTMnet; Q4VK74; -.
DR PhosphoSitePlus; Q4VK74; -.
DR PaxDb; Q4VK74; -.
DR PRIDE; Q4VK74; -.
DR DNASU; 330496; -.
DR Ensembl; ENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
DR GeneID; 330496; -.
DR KEGG; mmu:330496; -.
DR UCSC; uc009fzd.1; mouse.
DR CTD; 282616; -.
DR MGI; MGI:3647279; Ifnl2.
DR VEuPathDB; HostDB:ENSMUSG00000059128; -.
DR eggNOG; ENOG502SSDC; Eukaryota.
DR GeneTree; ENSGT00390000014310; -.
DR HOGENOM; CLU_120266_0_0_1; -.
DR InParanoid; Q4VK74; -.
DR OMA; HWLQKLE; -.
DR OrthoDB; 1429532at2759; -.
DR PhylomeDB; Q4VK74; -.
DR TreeFam; TF336172; -.
DR Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR BioGRID-ORCS; 330496; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q4VK74; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q4VK74; protein.
DR Bgee; ENSMUSG00000059128; Expressed in thymus and 1 other tissue.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0032002; C:interleukin-28 receptor complex; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0032003; F:interleukin-28 receptor binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0002385; P:mucosal immune response; IDA:UniProtKB.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:InterPro.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR Gene3D; 1.20.1250.60; -; 1.
DR InterPro; IPR038326; IFN-lambda_sf.
DR InterPro; IPR029177; INF_lambda.
DR PANTHER; PTHR31943; PTHR31943; 1.
DR Pfam; PF15177; IL28A; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..193
FT /note="Interferon lambda-2"
FT /id="PRO_0000345632"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 67
FT /note="L -> M (in Ref. 1; AAX58714)"
FT /evidence="ECO:0000305"
FT CONFLICT 74..75
FT /note="FP -> IS (in Ref. 1; AAX58714)"
FT /evidence="ECO:0000305"
FT CONFLICT 142..143
FT /note="RS -> KP (in Ref. 1; AAX58714)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="A -> D (in Ref. 1; AAX58714)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="N -> S (in Ref. 1; AAX58714)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 193 AA; 21740 MW; 42D7858FE245CC12 CRC64;
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKDAIEK
RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL KVWENMTDSA LATILGQPLH
TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR WLHRLQEAQS KETPGCLEAS VTSNLFRLLT
RDLKCVANGD QCV
