IFNL3_MOUSE
ID IFNL3_MOUSE Reviewed; 193 AA.
AC Q8CGK6; Q4VK73;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Interferon lambda-3;
DE Short=IFN-lambda-3;
DE AltName: Full=Interleukin-28B;
DE Short=IL-28B;
DE Flags: Precursor;
GN Name=Ifnl3; Synonyms=Il28, Il28b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12483210; DOI=10.1038/ni875;
RA Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M.,
RA Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.;
RT "IFN-lambdas mediate antiviral protection through a distinct class II
RT cytokine receptor complex.";
RL Nat. Immunol. 4:69-77(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=129/Sv;
RX PubMed=15914836; DOI=10.1099/vir.0.80904-0;
RA Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.;
RT "Murine interferon lambdas (type III interferons) exhibit potent antiviral
RT activity in vivo in a poxvirus infection model.";
RL J. Gen. Virol. 86:1589-1596(2005).
RN [3]
RP FUNCTION.
RX PubMed=16618774; DOI=10.1158/0008-5472.can-05-3653;
RA Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B.,
RA Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E.,
RA Kotenko S.V.;
RT "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-
RT lambdas exhibit antitumor activity against B16 melanoma.";
RL Cancer Res. 66:4468-4477(2006).
RN [4]
RP FUNCTION.
RX PubMed=18250457; DOI=10.4049/jimmunol.180.4.2474;
RA Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B.,
RA Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K.,
RA Paludan S.R.;
RT "An important role for type III interferon (IFN-lambda/IL-28) in TLR-
RT induced antiviral activity.";
RL J. Immunol. 180:2474-2485(2008).
RN [5]
RP REVIEW.
RX PubMed=20712453; DOI=10.1089/jir.2010.0078;
RA Donnelly R.P., Kotenko S.V.;
RT "Interferon-lambda: a new addition to an old family.";
RL J. Interferon Cytokine Res. 30:555-564(2010).
RN [6]
RP FUNCTION.
RX PubMed=21518880; DOI=10.1073/pnas.1100552108;
RA Pott J., Mahlakoiv T., Mordstein M., Duerr C.U., Michiels T.,
RA Stockinger S., Staeheli P., Hornef M.W.;
RT "IFN-lambda determines the intestinal epithelial antiviral host defense.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:7944-7949(2011).
RN [7]
RP REVIEW.
RX PubMed=24751921; DOI=10.1159/000360084;
RA Hermant P., Michiels T.;
RT "Interferon-lambda in the context of viral infections: production, response
RT and therapeutic implications.";
RL J. Innate Immun. 6:563-574(2014).
CC -!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
CC activities. Plays a critical role in the antiviral host defense,
CC predominantly in the epithelial tissues. Acts as a ligand for the
CC heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1,
CC and receptor engagement leads to the activation of the JAK/STAT
CC signaling pathway resulting in the expression of IFN-stimulated genes
CC (ISG), which mediate the antiviral state. Has a restricted receptor
CC distribution and therefore restricted targets: is primarily active in
CC epithelial cells and this cell type-selective action is because of the
CC epithelial cell-specific expression of its receptor IFNLR1. Seems not
CC to be essential for early virus-activated host defense in vaginal
CC infection, but plays an important role in Toll-like receptor (TLR)-
CC induced antiviral defense. Plays a significant role in the antiviral
CC immune defense in the intestinal epithelium. Exerts an immunomodulatory
CC effect by up-regulating MHC class I antigen expression.
CC {ECO:0000269|PubMed:15914836, ECO:0000269|PubMed:16618774,
CC ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lambda interferon family. {ECO:0000305}.
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DR EMBL; AY184375; AAN86128.1; -; mRNA.
DR EMBL; AY869696; AAX58715.1; -; mRNA.
DR CCDS; CCDS21047.1; -.
DR RefSeq; NP_796370.1; NM_177396.1.
DR AlphaFoldDB; Q8CGK6; -.
DR SMR; Q8CGK6; -.
DR STRING; 10090.ENSMUSP00000077473; -.
DR PhosphoSitePlus; Q8CGK6; -.
DR EPD; Q8CGK6; -.
DR PaxDb; Q8CGK6; -.
DR PRIDE; Q8CGK6; -.
DR DNASU; 338374; -.
DR Ensembl; ENSMUST00000078364; ENSMUSP00000077473; ENSMUSG00000060747.
DR GeneID; 338374; -.
DR KEGG; mmu:338374; -.
DR UCSC; uc009fze.1; mouse.
DR CTD; 282617; -.
DR MGI; MGI:2450574; Ifnl3.
DR VEuPathDB; HostDB:ENSMUSG00000060747; -.
DR eggNOG; ENOG502SSDC; Eukaryota.
DR GeneTree; ENSGT00390000014310; -.
DR HOGENOM; CLU_120266_0_0_1; -.
DR InParanoid; Q8CGK6; -.
DR OMA; KAWSCRP; -.
DR OrthoDB; 1429532at2759; -.
DR PhylomeDB; Q8CGK6; -.
DR TreeFam; TF336172; -.
DR Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR BioGRID-ORCS; 338374; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Ifnl3; mouse.
DR PRO; PR:Q8CGK6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8CGK6; protein.
DR Bgee; ENSMUSG00000060747; Expressed in thymus and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; ISA:MGI.
DR GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IDA:MGI.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:InterPro.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR Gene3D; 1.20.1250.60; -; 1.
DR InterPro; IPR038326; IFN-lambda_sf.
DR InterPro; IPR029177; INF_lambda.
DR PANTHER; PTHR31943; PTHR31943; 1.
DR Pfam; PF15177; IL28A; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..193
FT /note="Interferon lambda-3"
FT /id="PRO_0000015512"
FT DISULFID 35..132
FT /evidence="ECO:0000250"
FT DISULFID 69..166
FT /evidence="ECO:0000250"
FT DISULFID 185..192
FT /evidence="ECO:0000250"
FT CONFLICT 56
FT /note="G -> D (in Ref. 2; AAX58715)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="M -> V (in Ref. 2; AAX58715)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 193 AA; 21664 MW; 357A00AACAA9BC61 CRC64;
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKGAIEK
RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL KVWENINDSA LTTILGQPLH
TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR WLHRLQEAQS KETPGCLEDS VTSNLFQLLL
RDLKCVASGD QCV
