IFNW1_BOVIN
ID IFNW1_BOVIN Reviewed; 195 AA.
AC P07352;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Interferon omega-1;
DE AltName: Full=IFN-omega-c1;
DE AltName: Full=Interferon alpha-II-1;
DE Flags: Precursor;
GN Name=IFNW1; Synonyms=IFNW;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Pancreas;
RX PubMed=2985969; DOI=10.1128/mcb.5.4.768-779.1985;
RA Capon D.J., Shepard H.M., Goeddel D.V.;
RT "Two distinct families of human and bovine interferon-alpha genes are
RT coordinately expressed and encode functional polypeptides.";
RL Mol. Cell. Biol. 5:768-779(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Chung Y.G., Seidel G.E. Jr.;
RT "Cloning bovine interferon-tau genes and characterizing their
RT transcriptional expression during early pregnancy.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR EMBL; M11002; AAA30578.1; -; Genomic_DNA.
DR EMBL; AF238610; AAG14167.1; -; Genomic_DNA.
DR PIR; B23285; IVBOII.
DR RefSeq; NP_776776.1; NM_174351.1.
DR AlphaFoldDB; P07352; -.
DR SMR; P07352; -.
DR STRING; 9913.ENSBTAP00000055699; -.
DR PaxDb; P07352; -.
DR GeneID; 281847; -.
DR KEGG; bta:281847; -.
DR CTD; 3467; -.
DR eggNOG; ENOG502T289; Eukaryota.
DR HOGENOM; CLU_109427_0_0_1; -.
DR InParanoid; P07352; -.
DR OrthoDB; 1358010at2759; -.
DR TreeFam; TF336177; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691; PTHR11691; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..23
FT CHAIN 24..195
FT /note="Interferon omega-1"
FT /id="PRO_0000016405"
FT DISULFID 24..122
FT /evidence="ECO:0000250"
FT DISULFID 52..162
FT /evidence="ECO:0000250"
SQ SEQUENCE 195 AA; 21980 MW; 1B65FD4BCABB2A15 CRC64;
MAFVLSLLMA LVLVSYGPGG SLGCDLSPNH VLVGRQNLRL LGQMRRLSPR FCLQDRKDFA
FPQEMVEVSQ FQEAQAISVL HEMLQQSFNL FHKERSSAAW DTTLLEQLLT GLHQQLDDLD
ACLGLLTGEE DSALGRTGPT LAMKRYFQGI HVYLQEKGYS DCAWEIVRLE IMRSLSSSTS
LQERLRMMDG DLKSP