ID   IFN_ANAPL               Reviewed;         191 AA.
AC   P51526;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Interferon;
DE   Flags: Precursor;
GN   Name=IFN;
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=7571434; DOI=10.1006/viro.1995.1522;
RA   Schultz U., Koeck J., Schlicht H.J., Staeheli P.;
RT   "Recombinant duck interferon: a new reagent for studying the mode of
RT   interferon action against hepatitis B virus.";
RL   Virology 212:641-649(1995).
CC   -!- FUNCTION: Has antiviral activities.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: By viral infection.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; X84764; CAA59235.1; -; Genomic_DNA.
DR   PIR; S57642; S57642.
DR   AlphaFoldDB; P51526; -.
DR   SMR; P51526; -.
DR   Ensembl; ENSAPLT00020028982; ENSAPLP00020026913; ENSAPLG00020018289.
DR   Ensembl; ENSAPLT00020028985; ENSAPLP00020026916; ENSAPLG00020018290.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005132; F:type I interferon receptor binding; IEA:InterPro.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   InterPro; IPR015588; Interferon_beta.
DR   PANTHER; PTHR11691; PTHR11691; 1.
DR   PANTHER; PTHR11691:SF68; PTHR11691:SF68; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Secreted;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..191
FT                   /note="Interferon"
FT                   /id="PRO_0000016427"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        31..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..154
FT                   /evidence="ECO:0000255"
FT   DISULFID        67..167
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   191 AA;  21652 MW;  54D197AC899BB82F CRC64;
     MPGPSAPPPP AIYSALALLL LLTPPANAFS CSPLRLHDSA FAWDSLQLLR NMAPSPTQPC
     PQQHAPCSFP DTLLDTNDTQ QAAHTALHLL QHLFDTLSSP STPAHWLHTA RHDLLNQLQH
     HIHHLERCFP ADAARLHRRG PRNLHLSINK YFGCIQHFLQ NHTYSPCAWD HVRLEAHACF
     QRIHRLTRTM R