IFP1_CAEEL
ID IFP1_CAEEL Reviewed; 776 AA.
AC Q09501;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Intermediate filament protein ifp-1;
DE AltName: Full=Cel IF E1;
DE AltName: Full=Intermediate filament protein E1;
DE Short=IF-E1;
GN Name=ifp-1; ORFNames=C43C3.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=11427699; DOI=10.1073/pnas.121169998;
RA Karabinos A., Schmidt H., Harborth J., Schnabel R., Weber K.;
RT "Essential roles for four cytoplasmic intermediate filament proteins in
RT Caenorhabditis elegans development.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7863-7868(2001).
CC -!- FUNCTION: Cytoplasmic intermediate filaments provide mechanical
CC strength to cells. Not essential protein.
CC {ECO:0000269|PubMed:11427699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; Z47067; CAA87328.1; -; Genomic_DNA.
DR PIR; T19900; T19900.
DR RefSeq; NP_509628.1; NM_077227.4.
DR AlphaFoldDB; Q09501; -.
DR SMR; Q09501; -.
DR BioGRID; 46098; 8.
DR DIP; DIP-27211N; -.
DR IntAct; Q09501; 3.
DR STRING; 6239.C43C3.1; -.
DR iPTMnet; Q09501; -.
DR EPD; Q09501; -.
DR PaxDb; Q09501; -.
DR PeptideAtlas; Q09501; -.
DR PRIDE; Q09501; -.
DR EnsemblMetazoa; C43C3.1.1; C43C3.1.1; WBGene00002067.
DR GeneID; 181182; -.
DR KEGG; cel:CELE_C43C3.1; -.
DR UCSC; C43C3.1; c. elegans.
DR CTD; 181182; -.
DR WormBase; C43C3.1; CE01523; WBGene00002067; ifp-1.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00910000144343; -.
DR HOGENOM; CLU_020274_0_0_1; -.
DR InParanoid; Q09501; -.
DR OMA; FQRFTRW; -.
DR OrthoDB; 792778at2759; -.
DR PRO; PR:Q09501; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002067; Expressed in larva and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005652; C:nuclear lamina; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IBA:GO_Central.
DR GO; GO:0006998; P:nuclear envelope organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0051664; P:nuclear pore localization; IBA:GO_Central.
DR GO; GO:0090435; P:protein localization to nuclear envelope; IBA:GO_Central.
DR Gene3D; 2.60.40.1260; -; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR Pfam; PF00038; Filament; 1.
DR SUPFAM; SSF74853; SSF74853; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Intermediate filament; Reference proteome.
FT CHAIN 1..776
FT /note="Intermediate filament protein ifp-1"
FT /id="PRO_0000063845"
FT DOMAIN 20..371
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT DOMAIN 653..764
FT /note="LTD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01187"
FT REGION 1..23
FT /note="Head"
FT REGION 24..55
FT /note="Coil 1A"
FT REGION 56..69
FT /note="Linker 1"
FT REGION 70..207
FT /note="Coil 1B"
FT REGION 208..224
FT /note="Linker 12"
FT REGION 225..620
FT /note="Coil 2"
FT REGION 453..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..768
FT /note="Tail"
FT COMPBIAS 454..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 89051 MW; DB16A960B76D5B52 CRC64;
MDSANARDCL LHLARAKLSE RQDLVQLNDQ FVDIIEHVHY MEAEHTALEH DYNLLKSGVQ
SDSSGINEIY NVEIRTVRSG IEEINRSRHE LLNEQTQLSH QVKEAEQLWR HTAKSALGVP
KEVDDEFHRI CHIKMEDCIT KRRIKYMEDK LRLIKQNNGR IFEHINLMRM RKDQAVSLQQ
EYLLRKNELL HSIRNMEEDN KKIIMNEHKY FVRDRNADRH VFRDQLRKAI ADIRADYEAN
RLRNEEEIRI RLEREIHRMN TTMPGVVCYD KLREELSIVK NNLSGLQKQV SEVEIRNNSL
TQQIEFYRLE ISENNKLFED TLEFKIKEIE KMREQCTAIS VELEKLCDLN IDLQKEIAKY
RELLDRSGDP RANAPSTQVI ASALSRQNYS SISDHHSRTS SGIVQHTAHH AVRDSSSSRT
GTTIHETITH TPIPIPATLP VQPIREYTYS RDASPIRPSY TPYQQESRAD SRSSLRERIQ
IETLQGTLPV LPSHSVETIR ASDNTRLVRD LSAGGQINTT QINNPYASRT PTSSVNDRIA
SERRDSEIRR NDALHQPYPI GGAVPRVEPT IFNERAPGYT HINSNFPLIT PVTEGATVPS
YYDTFNRNSS QRGPHHSSYH AATGSVSNSI STTLLNEGSI EHSSSSDSVD EDNFQRFTRW
YKGRVKISDV TADFVQLVNR SSKKSADVGG FKLIHEFGNK SVYVDLPVGL ILAPKDSLKI
YARGATHERG AVIAEIDFFD TTIHTNTSIR NTNNEVKSWF VYTSNTEIGD ADHHHH
