IFRD1_MOUSE
ID IFRD1_MOUSE Reviewed; 449 AA.
AC P19182; P21835; P70228; Q80XM4;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Interferon-related developmental regulator 1;
DE AltName: Full=Nerve growth factor-inducible protein PC4;
DE AltName: Full=TPA-induced sequence 7;
DE Short=TIS7 protein;
GN Name=Ifrd1; Synonyms=Tis7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2797820;
RA Varnum B.C., Lim R.W., Herschman H.R.;
RT "Characterization of TIS7, a gene induced in Swiss 3T3 cells by the tumor
RT promoter tetradecanoyl phorbol acetate.";
RL Oncogene 4:1263-1265(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 386-449.
RX PubMed=6179042; DOI=10.1093/nar/10.10.3069;
RA Skup D., Windass J.D., Sor F.S., George H., Williams B.R., Fukuhara H.,
RA de Maeyer-Guignard J., de Maeyer E.;
RT "Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta
RT mRNAs.";
RL Nucleic Acids Res. 10:3069-3084(1982).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Could play a role in regulating gene activity in the
CC proliferative and/or differentiative pathways induced by NGF. May be an
CC autocrine factor that attenuates or amplifies the initial ligand-
CC induced signal.
CC -!- SUBUNIT: Interacts with PSIP1/LEDGF. {ECO:0000250}.
CC -!- INDUCTION: By mitogens such as TPA in 373 cells and by nerve growth
CC factor in PC12 pheochromocytoma cells.
CC -!- SIMILARITY: Belongs to the IFRD family. {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be interferon beta-2.
CC {ECO:0000305|PubMed:6179042}.
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DR EMBL; X17400; CAA35258.1; -; mRNA.
DR EMBL; CH466526; EDL36825.1; -; Genomic_DNA.
DR EMBL; BC043723; AAH43723.1; -; mRNA.
DR EMBL; V00756; CAA24133.1; ALT_SEQ; mRNA.
DR CCDS; CCDS25893.1; -.
DR PIR; A44989; A44989.
DR RefSeq; NP_038590.2; NM_013562.2.
DR AlphaFoldDB; P19182; -.
DR SMR; P19182; -.
DR BioGRID; 200544; 5.
DR CORUM; P19182; -.
DR IntAct; P19182; 1.
DR STRING; 10090.ENSMUSP00000001672; -.
DR iPTMnet; P19182; -.
DR PhosphoSitePlus; P19182; -.
DR EPD; P19182; -.
DR MaxQB; P19182; -.
DR PaxDb; P19182; -.
DR PeptideAtlas; P19182; -.
DR PRIDE; P19182; -.
DR ProteomicsDB; 269382; -.
DR DNASU; 15982; -.
DR Ensembl; ENSMUST00000001672; ENSMUSP00000001672; ENSMUSG00000001627.
DR GeneID; 15982; -.
DR KEGG; mmu:15982; -.
DR UCSC; uc007nky.2; mouse.
DR CTD; 3475; -.
DR MGI; MGI:1316717; Ifrd1.
DR VEuPathDB; HostDB:ENSMUSG00000001627; -.
DR eggNOG; KOG2842; Eukaryota.
DR GeneTree; ENSGT00390000013347; -.
DR HOGENOM; CLU_031384_1_0_1; -.
DR InParanoid; P19182; -.
DR OMA; VYNLSME; -.
DR OrthoDB; 1153292at2759; -.
DR PhylomeDB; P19182; -.
DR TreeFam; TF313638; -.
DR BioGRID-ORCS; 15982; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Ifrd1; mouse.
DR PRO; PR:P19182; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P19182; protein.
DR Bgee; ENSMUSG00000001627; Expressed in secondary oocyte and 281 other tissues.
DR ExpressionAtlas; P19182; baseline and differential.
DR Genevisible; P19182; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0016528; C:sarcoplasm; IDA:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0042692; P:muscle cell differentiation; IMP:MGI.
DR GO; GO:0030517; P:negative regulation of axon extension; IGI:MGI.
DR GO; GO:0048671; P:negative regulation of collateral sprouting; IGI:MGI.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:MGI.
DR GO; GO:0014706; P:striated muscle tissue development; IMP:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039777; IFRD.
DR InterPro; IPR006921; Interferon-rel_develop_reg_C.
DR InterPro; IPR007701; Interferon-rel_develop_reg_N.
DR PANTHER; PTHR12354; PTHR12354; 1.
DR Pfam; PF05004; IFRD; 1.
DR Pfam; PF04836; IFRD_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Reference proteome.
FT CHAIN 1..449
FT /note="Interferon-related developmental regulator 1"
FT /id="PRO_0000153286"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 43
FT /note="D -> H (in Ref. 1; CAA35258)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="L -> V (in Ref. 1; CAA35258)"
FT /evidence="ECO:0000305"
FT CONFLICT 399
FT /note="L -> V (in Ref. 4; CAA24133)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 49935 MW; 01ACFC575F8AE6E8 CRC64;
MPKNKKRNAP HRGGGGGGGS GAATSAATAG GPHRTVQPFS DEDASIETMS HCSGYSDPSS
FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA LEGLKNALSS KVLYEFVLER
RMTLTDSIER CLKKGKSDEQ RAAAAVASVL CIQLGPGFES EEILKTLGPI LKKIICDGAA
SIQARQTCAT CFGVCCFIAT DDITELYSTL ECFENIFTKS YLKEKDTNVT CSTPNTVLHI
SSLLAWTLLL TICPINEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES
DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP TETVKFGPER
MYIDSWVKKH TYDTFKEVLG SGMQYHLQTN EFLRNVFELG PPVMLDAATL KTMKISRFER
HLYNSAAFKA RTKARSKCRD KRADVGEFL
