ID   IFRD1_RAT               Reviewed;         449 AA.
AC   P20695;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Interferon-related developmental regulator 1;
DE   AltName: Full=IRPR;
DE   AltName: Full=Nerve growth factor-inducible protein PC4;
GN   Name=Ifrd1; Synonyms=Pc4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2467301; DOI=10.1073/pnas.86.6.2088;
RA   Tirone F., Shooter E.M.;
RT   "Early gene regulation by nerve growth factor in PC12 cells: induction of
RT   an interferon-related gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:2088-2092(1989).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=8028043; DOI=10.1002/jnr.490370514;
RA   Guardavaccaro D., Montagnoli A., Ciotti M.T., Gatti A., Lotti L.,
RA   di Lazzaro C., Torrisi M.R., Tirone F.;
RT   "Nerve growth factor regulates the subcellular localization of the nerve
RT   growth factor-inducible protein PC4 in PC12 cells.";
RL   J. Neurosci. Res. 37:660-674(1994).
CC   -!- FUNCTION: Probably participates in neurogenesis. Could play a role in
CC       regulating gene activity in the proliferative and/or differentiative
CC       pathways induced by NGF.
CC   -!- SUBUNIT: Interacts with PSIP1/LEDGF. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8028043}. Cell
CC       membrane {ECO:0000269|PubMed:8028043}. Nucleus
CC       {ECO:0000269|PubMed:8028043}. Note=Presents a NGF-dependent pattern of
CC       intracellular localization. With increasing amounts of NGF and besides
CC       being expressed in the cytoplasm, it is also localized in the plasma
CC       membrane (inner side) at the onset of NGF-induced differentiation, from
CC       where it disappears to reappear in the nuclei of differentiated cells.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in the embryonic brain in
CC       the period related to neuroblast proliferation and differentiation.
CC   -!- DEVELOPMENTAL STAGE: Activated at the onset of neuronal
CC       differentiation.
CC   -!- INDUCTION: By nerve growth factor.
CC   -!- SIMILARITY: Belongs to the IFRD family. {ECO:0000305}.
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DR   EMBL; J04511; AAC28946.1; -; mRNA.
DR   PIR; A30303; A30303.
DR   RefSeq; NP_062115.1; NM_019242.1.
DR   AlphaFoldDB; P20695; -.
DR   SMR; P20695; -.
DR   STRING; 10116.ENSRNOP00000067730; -.
DR   PaxDb; P20695; -.
DR   PRIDE; P20695; -.
DR   GeneID; 29596; -.
DR   KEGG; rno:29596; -.
DR   CTD; 3475; -.
DR   RGD; 2867; Ifrd1.
DR   eggNOG; KOG2842; Eukaryota.
DR   InParanoid; P20695; -.
DR   OrthoDB; 1153292at2759; -.
DR   PhylomeDB; P20695; -.
DR   PRO; PR:P20695; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:MGI.
DR   GO; GO:0014009; P:glial cell proliferation; IEP:RGD.
DR   GO; GO:0042692; P:muscle cell differentiation; ISO:RGD.
DR   GO; GO:0030517; P:negative regulation of axon extension; ISO:RGD.
DR   GO; GO:0048671; P:negative regulation of collateral sprouting; ISO:RGD.
DR   GO; GO:0007405; P:neuroblast proliferation; IEP:RGD.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0043403; P:skeletal muscle tissue regeneration; ISO:RGD.
DR   GO; GO:0014706; P:striated muscle tissue development; ISO:RGD.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039777; IFRD.
DR   InterPro; IPR006921; Interferon-rel_develop_reg_C.
DR   InterPro; IPR007701; Interferon-rel_develop_reg_N.
DR   PANTHER; PTHR12354; PTHR12354; 1.
DR   Pfam; PF05004; IFRD; 1.
DR   Pfam; PF04836; IFRD_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Developmental protein; Differentiation; Membrane;
KW   Neurogenesis; Nucleus; Reference proteome.
FT   CHAIN           1..449
FT                   /note="Interferon-related developmental regulator 1"
FT                   /id="PRO_0000153288"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  49783 MW;  E1385CC622942219 CRC64;
     MPKNKKRNAP HRGGGGGGGS GAATSAATTG GPHRTVQPFS DEDASIETMS HCSGYSDPSS
     FAEDGPEVLD EEGTQEDLEY KLKGLIDLTL DKSAKTRQAA LEGVKNALSS KVLYEFVLER
     RMTLTDSIER CLKKGKSDGQ RAAAALASVL CIQLGPGLES EEILKTLGPI LKKIICDGTA
     SIQARQTCAT CFGVCCFIAT DDITELYSTL ECLEGIFTKS YLKEKDTNVP CSTPNTVLHI
     SSLLAWTLLL TICPISEVKK KLELHFHKLP SLLSCDDVNM RIAAGESLAL LFELARGMES
     DFFYEDMDSL TQMLRALATD GNKHRAKVDK RKQRSVFRDV LRAVEERDFP TETVKFGPER
     MYIDSWVKKH TYDTFKEALG SGMQYHLQTN EFLRNVFELG PPVMLDAATL KTMKIPRFER
     HLYNSAAFKA RTKARSKCRD KRADVGEFF