IFRD2_HUMAN
ID IFRD2_HUMAN Reviewed; 506 AA.
AC Q12894; Q9BVB4; Q9UJ88;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Interferon-related developmental regulator 2;
DE AltName: Full=Protein SKMC15;
GN Name=IFRD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Buanne P., Incerti B., Tirone F.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-502.
RC TISSUE=Cervix, Kidney, Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 66-506 (ISOFORM 1/2).
RC TISSUE=Skeletal muscle;
RX PubMed=9050919; DOI=10.1007/s004390050368;
RA Latif F., Duh F.-M., Bader S., Sekido Y., Li H., Geil L., Zbar B.,
RA Minna J.D., Lerman M.I.;
RT "The human homolog of the rodent immediate early response genes, PC4 and
RT TIS7, resides in the lung cancer tumor suppressor gene region on chromosome
RT 3p21.";
RL Hum. Genet. 99:334-341(1997).
CC -!- INTERACTION:
CC Q12894; Q9Y6K5: OAS3; NbExp=2; IntAct=EBI-2512448, EBI-6115729;
CC Q12894-2; O75564-2: JRK; NbExp=3; IntAct=EBI-14102882, EBI-17181882;
CC Q12894-2; Q99750: MDFI; NbExp=3; IntAct=EBI-14102882, EBI-724076;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q12894-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q12894-2; Sequence=VSP_057033;
CC -!- TISSUE SPECIFICITY: Expressed in a variety of tissues.
CC -!- SIMILARITY: Belongs to the IFRD family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-65 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH01327.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH01676.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH07265.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH07437.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Y12395; CAA73027.1; -; mRNA.
DR EMBL; U73167; AAC02728.1; -; Genomic_DNA.
DR EMBL; CH471055; EAW65070.1; -; Genomic_DNA.
DR EMBL; BC001327; AAH01327.1; ALT_INIT; mRNA.
DR EMBL; BC001676; AAH01676.1; ALT_INIT; mRNA.
DR EMBL; BC007265; AAH07265.1; ALT_INIT; mRNA.
DR EMBL; BC007437; AAH07437.3; ALT_INIT; mRNA.
DR EMBL; BI826806; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U09585; AAC16924.1; -; mRNA.
DR RefSeq; NP_006755.4; NM_006764.4.
DR AlphaFoldDB; Q12894; -.
DR SMR; Q12894; -.
DR BioGRID; 113616; 30.
DR IntAct; Q12894; 23.
DR MINT; Q12894; -.
DR STRING; 9606.ENSP00000392316; -.
DR iPTMnet; Q12894; -.
DR PhosphoSitePlus; Q12894; -.
DR BioMuta; IFRD2; -.
DR DMDM; 327478577; -.
DR EPD; Q12894; -.
DR jPOST; Q12894; -.
DR MassIVE; Q12894; -.
DR MaxQB; Q12894; -.
DR PaxDb; Q12894; -.
DR PeptideAtlas; Q12894; -.
DR PRIDE; Q12894; -.
DR ProteomicsDB; 59008; -. [Q12894-1]
DR Antibodypedia; 7285; 170 antibodies from 26 providers.
DR DNASU; 7866; -.
DR Ensembl; ENST00000417626.8; ENSP00000402849.4; ENSG00000214706.12.
DR GeneID; 7866; -.
DR KEGG; hsa:7866; -.
DR UCSC; uc011bdp.2; human. [Q12894-1]
DR CTD; 7866; -.
DR DisGeNET; 7866; -.
DR GeneCards; IFRD2; -.
DR HGNC; HGNC:5457; IFRD2.
DR HPA; ENSG00000214706; Low tissue specificity.
DR MIM; 602725; gene.
DR neXtProt; NX_Q12894; -.
DR PharmGKB; PA29692; -.
DR VEuPathDB; HostDB:ENSG00000214706; -.
DR eggNOG; KOG2842; Eukaryota.
DR HOGENOM; CLU_031384_1_1_1; -.
DR InParanoid; Q12894; -.
DR OrthoDB; 1153292at2759; -.
DR PhylomeDB; Q12894; -.
DR TreeFam; TF313638; -.
DR PathwayCommons; Q12894; -.
DR SignaLink; Q12894; -.
DR BioGRID-ORCS; 7866; 13 hits in 1074 CRISPR screens.
DR ChiTaRS; IFRD2; human.
DR GenomeRNAi; 7866; -.
DR Pharos; Q12894; Tbio.
DR PRO; PR:Q12894; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q12894; protein.
DR Bgee; ENSG00000214706; Expressed in body of pancreas and 187 other tissues.
DR ExpressionAtlas; Q12894; baseline and differential.
DR Genevisible; Q12894; HS.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039777; IFRD.
DR InterPro; IPR006921; Interferon-rel_develop_reg_C.
DR InterPro; IPR007701; Interferon-rel_develop_reg_N.
DR PANTHER; PTHR12354; PTHR12354; 1.
DR Pfam; PF05004; IFRD; 1.
DR Pfam; PF04836; IFRD_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..506
FT /note="Interferon-related developmental regulator 2"
FT /id="PRO_0000153289"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..13
FT /note="MAWNSPSRRPVWQ -> MGPKKSWRSHFFPLPEVWLLLLLSQALSPSHGPQT
FT QAGVGLVWSVPLPSALRSQSCLGAPLRDASELTTVHLFPTRGWGARRALWVHSSASASS
FT AASRRRLRAQASGISSFSLVD (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_057033"
FT VARIANT 502
FT /note="R -> Q (in dbSNP:rs2229648)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029302"
SQ SEQUENCE 506 AA; 54814 MW; 07E026CEADF973E8 CRC64;
MAWNSPSRRP VWQGGAPRED GGARGVWLPS SGQVSAQRTG RRLVGLEPTP TGSLTPRPPR
PVPGMPRARK GNTLRKGGQR RGGGARSSAQ ADSGSSDDEA ASEARSTASE CPSLLSTTAE
DSLGGDVVDE QGQQEDLEEK LKEYVDCLTD KSAKTRQGAL ESLRLALASR LLPDFLLERR
LTLADALEKC LKKGKGEEQA LAAAVLGLLC VQLGPGPKGE ELFHSLQPLL VSVLSDSTAS
PAARLHCASA LGLGCYVAAA DIQDLVSCLA CLESVFSRFY GLGGSSTSPV VPASLHGLLS
AALQAWALLL TICPSTQISH ILDRQLPRLP QLLSSESVNL RIAAGETIAL LFELARDLEE
EFVYEDMEAL CSVLRTLATD SNKYRAKADR RRQRSTFRAV LHSVEGGECE EEIVRFGFEV
LYMDSWARHR IYAAFKEVLG SGMHHHLQNN ELLRDIFGLG PVLLLDATAL KACKVPRFEK
HLYNAAAFKA RTKARSRVRD KRADIL
