IFT1B_HUMAN
ID IFT1B_HUMAN Reviewed; 474 AA.
AC Q5T764; A7E245;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Interferon-induced protein with tetratricopeptide repeats 1B;
DE AltName: Full=Interferon-induced protein with tetratricopeptide repeats 1-like protein;
GN Name=IFIT1B; Synonyms=IFIT1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5T764; O14879: IFIT3; NbExp=6; IntAct=EBI-3507164, EBI-745127;
CC -!- SIMILARITY: Belongs to the IFIT family. {ECO:0000305}.
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DR EMBL; AL353751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW50139.1; -; Genomic_DNA.
DR EMBL; BC137368; AAI37369.1; -; mRNA.
DR EMBL; BC137369; AAI37370.1; -; mRNA.
DR EMBL; BC150189; AAI50190.1; -; mRNA.
DR CCDS; CCDS31242.1; -.
DR RefSeq; NP_001010987.1; NM_001010987.2.
DR AlphaFoldDB; Q5T764; -.
DR SMR; Q5T764; -.
DR BioGRID; 136196; 6.
DR IntAct; Q5T764; 7.
DR STRING; 9606.ENSP00000360874; -.
DR iPTMnet; Q5T764; -.
DR PhosphoSitePlus; Q5T764; -.
DR BioMuta; IFIT1B; -.
DR DMDM; 74762241; -.
DR EPD; Q5T764; -.
DR jPOST; Q5T764; -.
DR MassIVE; Q5T764; -.
DR MaxQB; Q5T764; -.
DR PaxDb; Q5T764; -.
DR PeptideAtlas; Q5T764; -.
DR PRIDE; Q5T764; -.
DR ProteomicsDB; 64644; -.
DR Antibodypedia; 48339; 56 antibodies from 16 providers.
DR DNASU; 439996; -.
DR Ensembl; ENST00000371809.3; ENSP00000360874.3; ENSG00000204010.3.
DR GeneID; 439996; -.
DR KEGG; hsa:439996; -.
DR MANE-Select; ENST00000371809.3; ENSP00000360874.3; NM_001010987.2; NP_001010987.1.
DR UCSC; uc001kgh.3; human.
DR CTD; 439996; -.
DR GeneCards; IFIT1B; -.
DR HGNC; HGNC:23442; IFIT1B.
DR HPA; ENSG00000204010; Tissue enriched (bone).
DR neXtProt; NX_Q5T764; -.
DR OpenTargets; ENSG00000204010; -.
DR PharmGKB; PA165548753; -.
DR VEuPathDB; HostDB:ENSG00000204010; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00950000182946; -.
DR HOGENOM; CLU_043482_1_0_1; -.
DR InParanoid; Q5T764; -.
DR OMA; ANPSRYR; -.
DR OrthoDB; 460948at2759; -.
DR PhylomeDB; Q5T764; -.
DR TreeFam; TF342671; -.
DR PathwayCommons; Q5T764; -.
DR SignaLink; Q5T764; -.
DR BioGRID-ORCS; 439996; 5 hits in 1060 CRISPR screens.
DR ChiTaRS; IFIT1B; human.
DR GenomeRNAi; 439996; -.
DR Pharos; Q5T764; Tdark.
DR PRO; PR:Q5T764; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T764; protein.
DR Bgee; ENSG00000204010; Expressed in bone marrow cell and 19 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:InterPro.
DR GO; GO:0071357; P:cellular response to type I interferon; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR024121; Interferon-induced_IFIT1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10271:SF16; PTHR10271:SF16; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..474
FT /note="Interferon-induced protein with tetratricopeptide
FT repeats 1B"
FT /id="PRO_0000285728"
FT REPEAT 52..85
FT /note="TPR 1"
FT REPEAT 95..128
FT /note="TPR 2"
FT REPEAT 139..174
FT /note="TPR 3"
FT REPEAT 182..216
FT /note="TPR 4"
FT REPEAT 251..284
FT /note="TPR 5"
FT REPEAT 340..373
FT /note="TPR 6"
FT REPEAT 378..412
FT /note="TPR 7"
FT REPEAT 437..470
FT /note="TPR 8"
FT COILED 61..85
FT /evidence="ECO:0000255"
FT VARIANT 188
FT /note="L -> P (in dbSNP:rs7072728)"
FT /id="VAR_052617"
SQ SEQUENCE 474 AA; 54993 MW; 163BB9DCFFCEF8DE CRC64;
MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY NVGIHNLLAY
VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN FAWVYYHMGR LAEAQTYLDK
VENTCKKFAN PSRYRMECPE VDCEEGWALA KCGGKNYERA KTCFEKALEG NPENPEFNTG
YAITVYRLDK FNTASGRNKA FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI
EEALTSISSQ AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI
QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY AEIGHHRKAE
EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT HYLKGLKIEK MSHSREKLLN
ALEKLAKRCI HQNVRVVESV SLLGLIHKLK GEVSDALLCY ERALRLAADL NPIF
