ID   IFT20_DANRE             Reviewed;         132 AA.
AC   Q66I67; Q6J505;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Intraflagellar transport protein 20 homolog;
GN   Name=ift20; ORFNames=zgc:103674;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15182712; DOI=10.1016/s0896-6273(04)00268-5;
RA   Tsujikawa M., Malicki J.;
RT   "Intraflagellar transport genes are essential for differentiation and
RT   survival of vertebrate sensory neurons.";
RL   Neuron 42:703-716(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliary process assembly. May play a role in the
CC       trafficking of ciliary membrane proteins from the Golgi complex to the
CC       cilium. Regulates the platelet-derived growth factor receptor-alpha
CC       (PDGFRA) signaling pathway. Plays an important role in spermatogenesis,
CC       particularly spermiogenesis, when germ cells form flagella.
CC       {ECO:0000250|UniProtKB:Q61025}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q61025}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY600453; AAT27466.1; -; mRNA.
DR   EMBL; BC081508; AAH81508.1; -; mRNA.
DR   RefSeq; NP_001001833.2; NM_001001833.2.
DR   RefSeq; XP_005157634.1; XM_005157577.3.
DR   AlphaFoldDB; Q66I67; -.
DR   SMR; Q66I67; -.
DR   STRING; 7955.ENSDARP00000059350; -.
DR   PaxDb; Q66I67; -.
DR   DNASU; 414930; -.
DR   GeneID; 414930; -.
DR   KEGG; dre:414930; -.
DR   CTD; 90410; -.
DR   ZFIN; ZDB-GENE-040614-2; ift20.
DR   eggNOG; ENOG502RYYR; Eukaryota.
DR   InParanoid; Q66I67; -.
DR   OrthoDB; 1589590at2759; -.
DR   PhylomeDB; Q66I67; -.
DR   TreeFam; TF319434; -.
DR   Reactome; R-DRE-5620924; Intraflagellar transport.
DR   PRO; PR:Q66I67; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; IDA:ZFIN.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IDA:ZFIN.
DR   GO; GO:0005929; C:cilium; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   GO; GO:2000583; P:regulation of platelet-derived growth factor receptor-alpha signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR028172; FT20.
DR   PANTHER; PTHR31978; PTHR31978; 1.
DR   Pfam; PF14931; IFT20; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoplasmic vesicle; Cytoskeleton; Differentiation; Golgi apparatus;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..132
FT                   /note="Intraflagellar transport protein 20 homolog"
FT                   /id="PRO_0000249305"
FT   COILED          74..123
FT                   /evidence="ECO:0000255"
FT   CONFLICT        90
FT                   /note="H -> Q (in Ref. 1; AAT27466)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   132 AA;  15287 MW;  A7B1FFDE19694CEB CRC64;
     MAKDPLAEAG LHFDELNKLR VLEPDVSQKT TELKEECEEF VDKIGQFQKI VGGLIELVDE
     LAKEAETEKM KAIGARNLLK SVEKQREAQH QQLQALIAEK KMQLERYRIE YEALQKVEAE
     QSEFIDQFIL QK