ID   IFT20_XENTR             Reviewed;         132 AA.
AC   Q66KL7;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Intraflagellar transport protein 20 homolog;
GN   Name=ift20; ORFNames=TGas049d15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliary process assembly. May play a role in the
CC       trafficking of ciliary membrane proteins from the Golgi complex to the
CC       cilium. Regulates the platelet-derived growth factor receptor-alpha
CC       (PDGFRA) signaling pathway. Plays an important role in spermatogenesis,
CC       particularly spermiogenesis, when germ cells form flagella.
CC       {ECO:0000250|UniProtKB:Q61025}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q61025}.
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DR   EMBL; CR762302; CAJ83749.1; -; mRNA.
DR   EMBL; BC080338; AAH80338.1; -; mRNA.
DR   RefSeq; NP_001007902.1; NM_001007901.1.
DR   AlphaFoldDB; Q66KL7; -.
DR   SMR; Q66KL7; -.
DR   STRING; 8364.ENSXETP00000042122; -.
DR   PaxDb; Q66KL7; -.
DR   DNASU; 493285; -.
DR   Ensembl; ENSXETT00000069320; ENSXETP00000067388; ENSXETG00000040696.
DR   GeneID; 493285; -.
DR   KEGG; xtr:493285; -.
DR   CTD; 90410; -.
DR   Xenbase; XB-GENE-966387; ift20.
DR   eggNOG; ENOG502RYYR; Eukaryota.
DR   HOGENOM; CLU_134163_2_0_1; -.
DR   InParanoid; Q66KL7; -.
DR   OrthoDB; 1589590at2759; -.
DR   PhylomeDB; Q66KL7; -.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000040696; Expressed in testis and 13 other tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051642; P:centrosome localization; IBA:GO_Central.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   GO; GO:2000583; P:regulation of platelet-derived growth factor receptor-alpha signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR028172; FT20.
DR   PANTHER; PTHR31978; PTHR31978; 1.
DR   Pfam; PF14931; IFT20; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoplasmic vesicle; Cytoskeleton; Differentiation; Golgi apparatus;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..132
FT                   /note="Intraflagellar transport protein 20 homolog"
FT                   /id="PRO_0000249308"
FT   COILED          87..114
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  15339 MW;  0602FB5ABA5C8638 CRC64;
     MARDSLSDAG LHFDELNKLR ILDPDVAQQT NELKEECRDF VDKIGHFQKV VGGLIELVDE
     LAKETENEKM KAIGARNLLK SIAKQREAQQ QQLYALIAEK KMQLERYRIE YEALCKVEAE
     QNEFIDQFNL QK