ID   IFT22_BOVIN             Reviewed;         185 AA.
AC   Q5E9J4; Q3T011;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Intraflagellar transport protein 22 homolog;
DE   AltName: Full=Rab-like protein 5;
GN   Name=IFT22; Synonyms=RABL5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase-like component of the intraflagellar transport
CC       (IFT) complex B. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC       IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC       IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5E9J4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5E9J4-2; Sequence=VSP_021111;
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BT020926; AAX08943.1; -; mRNA.
DR   EMBL; BC102614; AAI02615.1; -; mRNA.
DR   RefSeq; NP_001015612.1; NM_001015612.1. [Q5E9J4-1]
DR   RefSeq; XP_005225173.1; XM_005225116.3. [Q5E9J4-2]
DR   AlphaFoldDB; Q5E9J4; -.
DR   SMR; Q5E9J4; -.
DR   STRING; 9913.ENSBTAP00000019073; -.
DR   PaxDb; Q5E9J4; -.
DR   PRIDE; Q5E9J4; -.
DR   Ensembl; ENSBTAT00000019073; ENSBTAP00000019073; ENSBTAG00000014343. [Q5E9J4-1]
DR   Ensembl; ENSBTAT00000044314; ENSBTAP00000041821; ENSBTAG00000014343. [Q5E9J4-2]
DR   GeneID; 516107; -.
DR   KEGG; bta:516107; -.
DR   CTD; 64792; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014343; -.
DR   eggNOG; ENOG502RXD4; Eukaryota.
DR   GeneTree; ENSGT00940000167219; -.
DR   InParanoid; Q5E9J4; -.
DR   OMA; AGCRFEL; -.
DR   OrthoDB; 1428809at2759; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000014343; Expressed in semen and 106 other tissues.
DR   ExpressionAtlas; Q5E9J4; baseline.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; GTP-binding;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..185
FT                   /note="Intraflagellar transport protein 22 homolog"
FT                   /id="PRO_0000253732"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         63..67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         123..126
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         40..69
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_021111"
SQ   SEQUENCE   185 AA;  20872 MW;  533468071DBD31C6 CRC64;
     MLKAKILFVG PCESGKTVLA NFLTESSDIT EYNPTQGVRI LEFENPHVTS NNKGTGCEFE
     LWDCGGDPKF ESCWPALMKD SHGVVIVFNA DIPSHLKEIE TWYSCFVQQQ FLQNTQCLLI
     AHHKPGSGSD KDNPALAPPL NKLKLVHSNL EDDPEEIRME FIKYLRSIIN SVSESRDREE
     MSIIT