IFT22_CAEEL
ID IFT22_CAEEL Reviewed; 252 AA.
AC Q9XUC2;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Intraflagellar transport associated protein 2;
GN Name=ifta-2 {ECO:0000312|WormBase:T28F3.6};
GN ORFNames=T28F3.6 {ECO:0000312|WormBase:T28F3.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP FUNCTION.
RX PubMed=16968739; DOI=10.1242/jcs.03187;
RA Schafer J.C., Winkelbauer M.E., Williams C.L., Haycraft C.J., Desmond R.A.,
RA Yoder B.K.;
RT "IFTA-2 is a conserved cilia protein involved in pathways regulating
RT longevity and dauer formation in Caenorhabditis elegans.";
RL J. Cell Sci. 119:4088-4100(2006).
RN [3]
RP FUNCTION, IDENTIFICATION IN IFT COMPLEX B, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=28479320; DOI=10.1016/j.cub.2017.04.015;
RA Yi P., Li W.J., Dong M.Q., Ou G.;
RT "Dynein-driven retrograde intraflagellar transport is triphasic in C.
RT elegans sensory cilia.";
RL Curr. Biol. 27:1448-1461(2017).
CC -!- FUNCTION: Component of the intraflagellar transport (IFT) complex B
CC required for transport of proteins in the motile cilium
CC (PubMed:28479320). May be required for ciliary entrance and transport
CC of specific ciliary cargo proteins such as che-3 which are related to
CC motility (PubMed:28479320). Regulates specific signaling activities in
CC the cilia, such as the daf-2/insulin receptor-like transduction pathway
CC (PubMed:16968739). {ECO:0000269|PubMed:16968739,
CC ECO:0000269|PubMed:28479320}.
CC -!- SUBUNIT: Component of the IFT complex B composed of at least che-2,
CC che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81,
CC ifta-2, osm-1, osm-5 and osm-6. {ECO:0000269|PubMed:28479320}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:16968739}. Note=Moves along the axoneme.
CC -!- TISSUE SPECIFICITY: Ciliated sensory neurons.
CC {ECO:0000269|PubMed:16968739}.
CC -!- DISRUPTION PHENOTYPE: Worms have an extended lifespan phenotype and are
CC defective in dauer formation. {ECO:0000269|PubMed:16968739}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
CC -!- CAUTION: In contrast to other members of the family, does not contain a
CC prenylation domain. {ECO:0000305}.
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DR EMBL; Z82285; CAB05299.1; -; Genomic_DNA.
DR PIR; T25422; T25422.
DR RefSeq; NP_503073.1; NM_070672.3.
DR AlphaFoldDB; Q9XUC2; -.
DR SMR; Q9XUC2; -.
DR BioGRID; 53706; 6.
DR ComplexPortal; CPX-1290; Intraflagellar transport complex B.
DR STRING; 6239.T28F3.6; -.
DR EPD; Q9XUC2; -.
DR PaxDb; Q9XUC2; -.
DR EnsemblMetazoa; T28F3.6.1; T28F3.6.1; WBGene00012132.
DR GeneID; 189055; -.
DR KEGG; cel:CELE_T28F3.6; -.
DR UCSC; T28F3.6; c. elegans.
DR CTD; 189055; -.
DR WormBase; T28F3.6; CE20116; WBGene00012132; ifta-2.
DR eggNOG; ENOG502RXD4; Eukaryota.
DR HOGENOM; CLU_096604_0_0_1; -.
DR InParanoid; Q9XUC2; -.
DR OMA; CWPAIKE; -.
DR OrthoDB; 1428809at2759; -.
DR PhylomeDB; Q9XUC2; -.
DR Reactome; R-CEL-5620924; Intraflagellar transport.
DR PRO; PR:Q9XUC2; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00012132; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005930; C:axoneme; IDA:WormBase.
DR GO; GO:0097546; C:ciliary base; IDA:WormBase.
DR GO; GO:0005929; C:cilium; IC:ComplexPortal.
DR GO; GO:0030992; C:intraciliary transport particle B; IC:ComplexPortal.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0040024; P:dauer larval development; IMP:WormBase.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IGI:WormBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0042073; P:intraciliary transport; IC:ComplexPortal.
DR GO; GO:0008104; P:protein localization; IMP:WormBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; GTP-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..252
FT /note="Intraflagellar transport associated protein 2"
FT /id="PRO_0000429419"
FT BINDING 35..42
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 118..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 252 AA; 28860 MW; E257024A9C2B6480 CRC64;
MATENPQTWA LWLILSEMAS DMQEDKKVAK ILVLGPPKAG KTTLCTFLAD FMEDGDTLKK
GEDSGERERK FEFEFTSVYR PTKGVRIQEF ETHEFFTEQE QNELGGTRRL EDSEIQLWDV
SGDKKYEDCW PAIKENAEGV ILVVNPEEHK GSDLQQWFYE FVEKENIDLS CVMVILNEQG
AKKTNHEQIS GFEILPKLRG VHHVAHHFGS EAMQVKMEVN SFMASVLKMD QRQMGSGVDH
GLGYADEQED DF
