ID   IFT22_DANRE             Reviewed;         187 AA.
AC   Q567Y6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Intraflagellar transport protein 22 homolog;
DE   AltName: Full=Rab-like protein 5;
GN   Name=ift22; Synonyms=rabl5; ORFNames=zgc:110645;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC092964; AAH92964.1; -; mRNA.
DR   RefSeq; NP_001017884.1; NM_001017884.1.
DR   AlphaFoldDB; Q567Y6; -.
DR   SMR; Q567Y6; -.
DR   STRING; 7955.ENSDARP00000011140; -.
DR   PaxDb; Q567Y6; -.
DR   Ensembl; ENSDART00000016709; ENSDARP00000011140; ENSDARG00000020822.
DR   GeneID; 550583; -.
DR   KEGG; dre:550583; -.
DR   CTD; 64792; -.
DR   ZFIN; ZDB-GENE-050417-439; ift22.
DR   eggNOG; ENOG502RXD4; Eukaryota.
DR   GeneTree; ENSGT00390000013187; -.
DR   HOGENOM; CLU_096604_0_0_1; -.
DR   InParanoid; Q567Y6; -.
DR   OMA; AGCRFEL; -.
DR   OrthoDB; 1428809at2759; -.
DR   PhylomeDB; Q567Y6; -.
DR   TreeFam; TF313208; -.
DR   Reactome; R-DRE-5620924; Intraflagellar transport.
DR   PRO; PR:Q567Y6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000020822; Expressed in testis and 22 other tissues.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..187
FT                   /note="Intraflagellar transport protein 22 homolog"
FT                   /id="PRO_0000253737"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         65..69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   187 AA;  20816 MW;  53938518EE4B6C84 CRC64;
     MFKVKILLIG PSECGKTALA NFLSDTTESI GADYSPTQGV RILEFESHNL HNGNKSSSCD
     VELWDCAGDF KFESCWPALM KDSNGVAVVF NPDVPSHLKE IETWYSAFIS SQGLLEGQCL
     LIAHHKPGSG ADTNRPSLAP QLNKLPLIHS NLEEEPEEVR QEFNKYLGKV MRMLSESQER
     EEMSIIT