IFT22_RAT
ID IFT22_RAT Reviewed; 185 AA.
AC Q5FVJ7;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Intraflagellar transport protein 22 homolog;
DE AltName: Full=Rab-like protein 5;
GN Name=Ift22; Synonyms=Rabl5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Small GTPase-like component of the intraflagellar transport
CC (IFT) complex B. {ECO:0000250}.
CC -!- SUBUNIT: Component of the IFT complex B, at least composed of IFT20,
CC IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74,
CC IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; BC089940; AAH89940.1; -; mRNA.
DR RefSeq; NP_001011902.1; NM_001011902.1.
DR AlphaFoldDB; Q5FVJ7; -.
DR SMR; Q5FVJ7; -.
DR STRING; 10116.ENSRNOP00000041226; -.
DR PhosphoSitePlus; Q5FVJ7; -.
DR PaxDb; Q5FVJ7; -.
DR PRIDE; Q5FVJ7; -.
DR GeneID; 288585; -.
DR KEGG; rno:288585; -.
DR UCSC; RGD:1305370; rat.
DR CTD; 64792; -.
DR RGD; 1305370; Ift22.
DR VEuPathDB; HostDB:ENSRNOG00000031346; -.
DR eggNOG; ENOG502RXD4; Eukaryota.
DR HOGENOM; CLU_096604_0_0_1; -.
DR InParanoid; Q5FVJ7; -.
DR OMA; AGCRFEL; -.
DR OrthoDB; 1428809at2759; -.
DR PhylomeDB; Q5FVJ7; -.
DR TreeFam; TF313208; -.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:Q5FVJ7; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000031346; Expressed in testis and 18 other tissues.
DR Genevisible; Q5FVJ7; RN.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; GTP-binding; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..185
FT /note="Intraflagellar transport protein 22 homolog"
FT /id="PRO_0000253736"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 123..126
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H7X7"
SQ SEQUENCE 185 AA; 20848 MW; CAFB57E743545C15 CRC64;
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYNPTQGVRI LEFENPHVTS NNKGTGCEFE
LWDCGGDSKF ESCWPALMKD AHGVVIVFNA DIPSHLKEIE MWYSCFVQQQ FLQDSHCMLV
AHHKPGSGGD KSNLALSPPL NKLKLVHSNL EEDPEEVRVE FIKYLKSIIN SMSESRDREE
MLIIT
