ID   IFT22_XENTR             Reviewed;         184 AA.
AC   Q5M8K8;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Intraflagellar transport protein 22 homolog;
DE   AltName: Full=Rab-like protein 5;
GN   Name=ift22; Synonyms=rabl5; ORFNames=TGas031j16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; CR848650; CAJ83977.1; -; mRNA.
DR   EMBL; BC087980; AAH87980.1; -; mRNA.
DR   RefSeq; NP_001011271.1; NM_001011271.1.
DR   RefSeq; XP_012812305.1; XM_012956851.2.
DR   RefSeq; XP_012812306.1; XM_012956852.2.
DR   RefSeq; XP_012812307.1; XM_012956853.2.
DR   RefSeq; XP_012812308.1; XM_012956854.2.
DR   RefSeq; XP_017946692.1; XM_018091203.1.
DR   RefSeq; XP_017946693.1; XM_018091204.1.
DR   AlphaFoldDB; Q5M8K8; -.
DR   SMR; Q5M8K8; -.
DR   STRING; 8364.ENSXETP00000027320; -.
DR   PaxDb; Q5M8K8; -.
DR   DNASU; 496722; -.
DR   Ensembl; ENSXETT00000027320; ENSXETP00000027320; ENSXETG00000012497.
DR   GeneID; 496722; -.
DR   KEGG; xtr:496722; -.
DR   CTD; 64792; -.
DR   Xenbase; XB-GENE-977482; ift22.
DR   eggNOG; ENOG502RXD4; Eukaryota.
DR   HOGENOM; CLU_096604_0_0_1; -.
DR   InParanoid; Q5M8K8; -.
DR   OMA; CWPAIKE; -.
DR   OrthoDB; 1428809at2759; -.
DR   PhylomeDB; Q5M8K8; -.
DR   TreeFam; TF313208; -.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000012497; Expressed in testis and 15 other tissues.
DR   ExpressionAtlas; Q5M8K8; baseline.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..184
FT                   /note="Intraflagellar transport protein 22 homolog"
FT                   /id="PRO_0000253738"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         62..66
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         122..125
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   184 AA;  20704 MW;  4C3745B7A688A759 CRC64;
     MFKAKVLVVG PTESGKTILA NFISDATETI GGEYNPTQGV RILEFECPNG NKGSSCEVEL
     WDCGGDSKFE SCWPVIMKDS HGVIIVFSAD IPSHLKEIEM WHLNFIQKQR LQENRCLLIA
     HKKPGSGDER ERLNLSPALA KLTLIYSNLE DDPEDVRMEL MKYLRGIVSS LSESRDREEM
     SIIT