IFT43_BOVIN
ID IFT43_BOVIN Reviewed; 207 AA.
AC Q2TBN9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Intraflagellar transport protein 43 homolog;
GN Name=IFT43;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As a component of IFT complex A (IFT-A), a complex required
CC for retrograde ciliary transport and entry into cilia of G protein-
CC coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in
CC retrograde ciliary transport along microtubules from the ciliary tip to
CC the base. {ECO:0000250|UniProtKB:Q96FT9}.
CC -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex. IFT-A complex
CC is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which
CC is associated with TULP3 and a peripheral subcomplex composed of
CC IFT43:WDR35:TTC21B. Interacts directy with IFT122, WDR35 and TTC21B.
CC {ECO:0000250|UniProtKB:Q96FT9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q96FT9}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q96FT9}. Note=Associated with microtubules.
CC Localized at the distal tip of the cilium.
CC {ECO:0000250|UniProtKB:Q96FT9}.
CC -!- SIMILARITY: Belongs to the IFT43 family. {ECO:0000305}.
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DR EMBL; BC109881; AAI09882.1; -; mRNA.
DR RefSeq; NP_001035611.1; NM_001040521.2.
DR AlphaFoldDB; Q2TBN9; -.
DR STRING; 9913.ENSBTAP00000015927; -.
DR PaxDb; Q2TBN9; -.
DR PRIDE; Q2TBN9; -.
DR GeneID; 513228; -.
DR KEGG; bta:513228; -.
DR CTD; 112752; -.
DR eggNOG; ENOG502RXJ2; Eukaryota.
DR InParanoid; Q2TBN9; -.
DR OrthoDB; 1272229at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR InterPro; IPR029302; IFT43.
DR PANTHER; PTHR33724; PTHR33724; 1.
DR Pfam; PF15305; IFT43; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..207
FT /note="Intraflagellar transport protein 43 homolog"
FT /id="PRO_0000254040"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96FT9"
FT MOD_RES 77
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96FT9"
SQ SEQUENCE 207 AA; 23440 MW; B6F439DBBC95FCC1 CRC64;
MEDLLDLGEE RRRCPATSGA KMGRRAQQES TQAENHLSGK NSSLTLTAEV PPPKPPRRQG
RWAEASVKVS KSQRRASEEI QDHRLRQQSL DRSDDGGDIP VIPDLEEVQE EDFVLQVAAP
PSIQVNRVMT YRDLDNDLMK YSAFQTLDGE IDLKLLTKVL APEHEVREDD VSWDWDHLYT
EVSSELLSEW DALQTEKEGP VGQPAHT
